McGrath Daniel R, Spigelman Allan D
Surgical Registrar Norfolk & Norwich University Hospital, Norwich, UK.
Expert Opin Ther Targets. 2008 Jun;12(6):729-38. doi: 10.1517/14728222.12.6.729.
Multiple factors are known to contribute to the development of cancer and numerous agents have been shown to confer some protection. Diets high in vegetables, especially cruciferous vegetables (broccoli, Brussels sprouts, cabbage etc.) provide such protection.
To define the phytonutrients within this group of vegetables and how their chemoprotective properties might be conferred.
Cruciferous vegetables provide the only human dietary source of a class of phytonutrients, the glucosinolates. The glucosinolate breakdown products, which include indole-3-carbinol and sulforaphane, have demonstrated various anticancer actions in laboratory studies. We give a brief overview of current understanding of the chemopreventive pathways for indole-3-carbinol in various human cancers and how this may relate, in particular, to colorectal cancer; the supporting evidence; and our opinion of its anticancer properties. The review is limited by the lack of bioavailability data in humans.
Indole-3-carbinol interacts with a multitude of intracellular processes, which may halt tumourgenesis and induce apoptosis.
已知多种因素会促使癌症发生，并且已证实多种物质具有一定的预防作用。富含蔬菜的饮食，尤其是十字花科蔬菜（西兰花、抱子甘蓝、卷心菜等）具有这种预防作用。
确定这类蔬菜中的植物营养素，以及它们的化学预防特性是如何发挥作用的。
十字花科蔬菜是一类植物营养素——硫代葡萄糖苷的唯一人类饮食来源。硫代葡萄糖苷的分解产物，包括吲哚 - 3 - 甲醇和萝卜硫素，在实验室研究中已显示出多种抗癌作用。我们简要概述了目前对吲哚 - 3 - 甲醇在各种人类癌症中的化学预防途径的理解，以及它与结直肠癌的具体关系、支持证据，还有我们对其抗癌特性的看法。由于缺乏人体生物利用度数据，本综述存在一定局限性。
吲哚 - 3 - 甲醇与多种细胞内过程相互作用，这可能会阻止肿瘤发生并诱导细胞凋亡。
