Taibi Diana M, Vitiello Michael V, Barsness Suzanne, Elmer Gary W, Anderson Gail D, Landis Carol A
Department of Biobehavioral Nursing & Health Systems, School of Nursing, University of Washington, Box 357266, Seattle, WA 98195-7262, USA.
Sleep Med. 2009 Mar;10(3):319-28. doi: 10.1016/j.sleep.2008.02.001. Epub 2008 May 14.
To test the effects of nightly valerian (Valeriana officinalis) extract to improve sleep of older women with insomnia.
Participants in this phase 2 randomized, double-blind, crossover controlled trial were 16 older women (mean age=69.4+/-8.1 years) with insomnia. Participants took 300 mg of concentrated valerian extract or placebo 30 min before bedtime for 2 weeks. Sleep was assessed in the laboratory by self-report and polysomnography (PSG) at baseline and again at the beginning and end of each treatment phase (total of nine nights in the laboratory) and at home by daily sleep logs and actigraphy.
There were no statistically significant differences between valerian and placebo after a single dose or after 2 weeks of nightly dosing on any measure of sleep latency, wake after sleep onset (WASO), sleep efficiency, and self-rated sleep quality. In comparing each treatment to baseline in separate comparisons, WASO significantly increased (+17.7+/-25.6 min, p=.02) after 2 weeks of nightly valerian, but not after placebo (+6.8+/-26.4 min, NS). Side effects were minor and did not differ significantly between valerian and placebo.
Valerian did not improve sleep in this sample of older women with insomnia. Findings from this study add to the scientific evidence that does not support use of valerian in the clinical management of insomnia.
测试夜间服用缬草提取物对改善老年失眠女性睡眠的效果。
本2期随机、双盲、交叉对照试验的参与者为16名患有失眠的老年女性（平均年龄=69.4±8.1岁）。参与者在睡前30分钟服用300毫克浓缩缬草提取物或安慰剂，持续2周。在实验室通过自我报告和多导睡眠图（PSG）在基线时以及每个治疗阶段开始和结束时（总共在实验室九个晚上）评估睡眠情况，并通过每日睡眠日志和活动记录仪在家中进行评估。
在单次给药后或夜间给药2周后，缬草和安慰剂在任何睡眠潜伏期、睡眠开始后觉醒（WASO）、睡眠效率和自我评定睡眠质量的测量指标上均无统计学显著差异。在将每种治疗与基线进行单独比较时，夜间服用缬草2周后WASO显著增加（+17.7±25.6分钟，p=0.02），而服用安慰剂后未增加（+6.8±26.4分钟，无统计学意义）。副作用轻微，缬草和安慰剂之间无显著差异。
缬草对该样本中的老年失眠女性睡眠没有改善作用。本研究结果补充了不支持在失眠临床管理中使用缬草的科学证据。
