Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Fitoterapia. 2010 Oct;81(7):948-52. doi: 10.1016/j.fitote.2010.06.015. Epub 2010 Jun 21.
Three new diarylheptanoids, together with ten known ones, were isolated from the ethanol extract from the rhizomes of Alpinia officinarum Hance. The structural identification of these compounds was mainly achieved by spectroscopic methods. The new compounds were elucidated as 7-(4", 5"-dihydroxy-3"-methoxyphenyl)-1-phenyl -4-heptene-3-one (1), 1, 7-diphenyl-5-heptene-3-one (2) and 4-phenethyl-1, 7-diphenyl -1-heptene-3, 5-dione (3), respectively. All of the compounds showed antibacterial activity against Helicobactor pylori. Especially, the three new compounds showed strong antibacterial activity against Hp-Sydney strain 1 with the MIC values of 9-12 μg/mL, and against Hp-F44 with the MIC values of 25-30 μg/mL.
从高良姜的根茎的乙醇提取物中分离得到了三种新的二芳基庚烷类化合物，以及十种已知化合物。这些化合物的结构鉴定主要通过光谱方法实现。新化合物被阐明为 7-(4"，5"-二羟基-3"-甲氧基苯基)-1-苯基-4-庚烯-3-酮（1）、1,7-二苯基-5-庚烯-3-酮（2）和 4-苯乙基-1,7-二苯基-1-庚烯-3,5-二酮（3）。所有化合物均显示出对幽门螺杆菌的抗菌活性。特别是，这三种新化合物对 Hp-Sydney 菌株 1 的 MIC 值为 9-12μg/mL，对 Hp-F44 的 MIC 值为 25-30μg/mL，表现出很强的抗菌活性。
