Wright Penny, Marshall Laura, Smith Adam B, Velikova Galina, Selby Peter
Psychosocial and Clinical Practice Research Group, Cancer Research UK Clinical Centre, Section of Oncology and Clinical Research, University of Leeds, St James's University Hospital, Beckett Street, Leeds LS9 7TF, United Kingdom.
Eur J Cancer. 2008 Jul;44(11):1529-35. doi: 10.1016/j.ejca.2008.04.011. Epub 2008 May 15.
Cancer has a significant social impact. There is a requirement to undertake formal assessment of this in research and clinical practice.
To establish values of clinically meaningful differences and changes in social distress (SOCD) using the social difficulties inventory (SDI).
Newly diagnosed patients treated with curative intent completed the SDI and the EORTC quality of life questionnaire (EORTC QLQ-C30) at baseline, 6, 12 and 24 months. Minimally important differences (MIDs) were estimated using anchor and distribution methods.
One hundred and eighty-eight patients participated. SOCD was elevated at baseline demonstrating the social burden of cancer on patients following diagnosis. Anchor estimates for MIDs were by age groups 3.37 and in comparison to EORTC QLQ-C30 social functioning scale from 0 to 6.27. Using distribution methods: SEM 2.01-4.92 and SD 1.67-3.57.
For general guidance, an estimate of 3 (range 0-44) is recommended as a clinically important difference, illustrated by case studies and group comparisons.
癌症具有重大的社会影响。在研究和临床实践中需要对此进行正式评估。
使用社会困难量表（SDI）确定具有临床意义的差异值以及社会困扰（SOCD）的变化情况。
接受根治性治疗的新诊断患者在基线、6个月、12个月和24个月时完成SDI和欧洲癌症研究与治疗组织生活质量问卷（EORTC QLQ-C30）。使用锚定法和分布法估计最小重要差异（MIDs）。
188名患者参与。基线时SOCD升高，表明癌症诊断后对患者的社会负担。按年龄组划分的MIDs锚定估计值为3.37，与EORTC QLQ-C30社会功能量表相比为0至6.27。使用分布法：标准误2.01 - 4.92，标准差1.67 - 3.57。
作为一般指导，建议将3（范围0 - 44）的估计值作为具有临床重要意义的差异，通过案例研究和组间比较说明。
