Liao Lawrence, Allen Larry A, Whellan David J
The Duke Clinical Research Institute, Durham, NC, USA.
Pharmacoeconomics. 2008;26(6):447-62. doi: 10.2165/00019053-200826060-00001.
Heart failure (HF) ranks among the most costly chronic diseases in developed countries. At present these countries devote 1-2% of all healthcare expenditures towards HF. In the US, these costs are estimated at $US30.2 billion for 2007. The burden of HF is greatest among the elderly, with 80% of HF hospitalizations and 90% of HF-related deaths in this cohort. As a result, approximately three-quarters of the resources for HF care are consumed by elderly patients. As demographic shifts increase the number of elderly individuals in both developed and developing nations, the resources devoted to HF care will likely further increase. Hospitalization accounts for roughly two-thirds of HF costs, but procedures, outpatient visits and medications also consume significant financial resources. HF also adversely impacts patient quality of life, and these relevant effects may not be captured in pure cost analyses. The cost effectiveness of several pharmacological interventions has been explored. In general, neurohormonal antagonists used for outpatient treatment of chronic HF are relatively cost effective, in part by reducing hospitalizations. Because HF poses such an enormous financial burden, efficient resource allocation for its management is a major societal and governmental challenge. In order to make informed decisions and allocate resources for HF care rationally, detailed data regarding costs and resource use will be essential. Further studies are needed to examine the impact of pharmacological and non-pharmacological interventions on costs and resource use in elderly individuals with HF.
心力衰竭(HF)在发达国家是成本最高的慢性病之一。目前,这些国家将所有医疗保健支出的1%-2%用于HF。在美国,2007年这些费用估计为302亿美元。HF的负担在老年人中最为严重,该年龄段80%的HF住院病例和90%的HF相关死亡病例都出现在这一人群中。因此,约四分之三的HF护理资源被老年患者消耗。随着人口结构的变化,发达国家和发展中国家的老年人口数量都在增加,用于HF护理的资源可能会进一步增加。住院费用约占HF总费用的三分之二,但手术、门诊就诊和药物治疗也消耗大量财政资源。HF还会对患者的生活质量产生不利影响,而这些相关影响可能无法在单纯的成本分析中体现出来。已经对几种药物干预措施的成本效益进行了探讨。一般来说,用于慢性HF门诊治疗的神经激素拮抗剂相对具有成本效益,部分原因是减少了住院次数。由于HF带来了如此巨大的财政负担,对其管理进行有效的资源分配是一项重大的社会和政府挑战。为了做出明智的决策并合理分配HF护理资源,有关成本和资源使用的详细数据至关重要。需要进一步研究来考察药物和非药物干预措施对老年HF患者成本和资源使用的影响。