Matsui Hidenori, Aikawa Chihiro, Sekiya Yukie, Takahashi Shinichi, Murayama Somay Yamagata, Nakamura Masahiko
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641 Japan.
Antimicrob Agents Chemother. 2008 Aug;52(8):2988-9. doi: 10.1128/AAC.01662-07. Epub 2008 May 19.
Triple-agent therapy with lansoprazole (15 mg/kg)-clarithromycin (50 mg/kg)-amoxicillin (50 mg/kg) twice daily for 7 days fully cleared "Candidatus Helicobacter heilmannii" from infected mouse stomachs. Moreover, gastric mucosa-associated lymphoid tissue lymphoma-like lesions in the stomach nearly disappeared in the treated mice 4 months after the therapy.
采用兰索拉唑(15毫克/千克)-克拉霉素(50毫克/千克)-阿莫西林(50毫克/千克)三联疗法,每日两次,持续7天,可使感染小鼠胃内的“海氏螺杆菌(暂未确定种属)”完全清除。此外,治疗后4个月,接受治疗的小鼠胃内的胃黏膜相关淋巴组织淋巴瘤样病变几乎消失。