Bento-Miranda Mario, Figueiredo Ceu
Mario Bento-Miranda, Ceu Figueiredo, Department of Pathology and Oncology, Faculty of Medicine of the University of Porto, 4200-465 Porto, Portugal.
World J Gastroenterol. 2014 Dec 21;20(47):17779-87. doi: 10.3748/wjg.v20.i47.17779.
Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections.
广义海氏螺杆菌（Helicobacter heilmannii sensu lato，H. heilmannii s.l.）是一组胃部非幽门螺杆菌的螺杆菌属物种，它们在形态上彼此难以区分。H. heilmannii s.l. 感染多种动物的胃部，可能具有人畜共患病的潜力。尽管这些感染在人类中的患病率较低，但它们与胃部病变有关，包括黏膜相关淋巴组织淋巴瘤，这使其成为一个重要的健康问题。在此，将对这些感染的分类学、流行病学、微生物学、诊断和治疗进行综述。还将探讨与人类H. heilmannii s.l. 感染相关的胃部病变。最后，将综述现有完整细菌基因组的特征以及物种特异性发病机制的研究。了解构成H. heilmannii s.l. 的不同细菌物种介导胃部疾病发展的机制，对于制定这些感染的预防和治疗策略至关重要。
