González-Martínez Haydeé, Rodríguez Leonor, Nájera Oralia, Cruz David, Miliar Angel, Domínguez Aarón, Sánchez Fausto, Graniel Jaime, González-Torres María Cristina
Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco, No. 186. Col. Vicentina, C.P. 09340, México, D.F., México.
J Clin Immunol. 2008 Sep;28(5):593-9. doi: 10.1007/s10875-008-9204-5. Epub 2008 May 22.
Protein-calorie malnutrition represents a significant worldwide health problem and is associated with an increased risk for infections. The purpose of this study was to evaluate possible changes in type 1/type 2 responses balance in malnourished children.
The data obtained in the present study showed that the expression levels of tumor necrosis factor-alpha, interleukin (IL)-4, and IL-10 were more highly, in contrast IL-2, gamma interferon, and IL-6 genes were expressed less in all groups of malnourished children compared with the well-nourished infected children. It is important to indicate that the data collected in the present work agree with the results obtained by different authors, who showed differences in the production of cytokines in malnourished children.
In conclusion, the results suggest that alterations in the balance of type 1/type 2 immune responses exist in malnourished children, and this could be the reason that the immunological system of the malnourished children is incapable of eradicating infections.
蛋白质 - 热量营养不良是一个全球性的重大健康问题，并且与感染风险增加相关。本研究的目的是评估营养不良儿童1型/2型反应平衡的可能变化。
本研究获得的数据表明，与营养良好的感染儿童相比，所有营养不良儿童组中肿瘤坏死因子 -α、白细胞介素（IL）-4和IL -10的表达水平更高，相反，IL -2、γ干扰素和IL -6基因的表达较少。必须指出的是，本研究收集的数据与不同作者获得的结果一致，这些作者表明营养不良儿童细胞因子的产生存在差异。
总之，结果表明营养不良儿童存在1型/2型免疫反应平衡的改变，这可能是营养不良儿童免疫系统无法根除感染的原因。
