人脐内皮衍生舒张因子的特性与作用
Characterization and actions of human umbilical endothelium derived relaxing factor.
作者信息
Chaudhuri G, Buga G M, Gold M E, Wood K S, Ignarro L J
机构信息
Department of Obstetrics & Gynecology, University of California, School of Medicine, Los Angeles 90024.
出版信息
Br J Pharmacol. 1991 Feb;102(2):331-6. doi: 10.1111/j.1476-5381.1991.tb12174.x.
Abstract
- A bioassay cascade superfusion technique was utilized to study the properties of endothelium derived relaxing factor (EDRF) from human umbilical vein (HUV) and compare its actions on umbilical, chorionic plate and bovine pulmonary arterial strips. 2. Histamine (1 microM), bradykinin (1 microM) and A-23187 (0.3 microM, 1 microM) but not acetylcholine (1 microM) released EDRF. 3. The non-innervated human foetoplacental vessels, i.e., umbilical and chorionic plate arteries, do relax to EDRF by a guanosine 3':5'-cyclic monophosphate (cyclic GMP)-mediated mechanism. 4. The sensitivity of the human umbilical arterial strips to EDRF was less than that of the chronic plate arterial strips. Bovine pulmonary arterial strips were the most sensitive to the relaxant actions of human umbilical EDRF.
摘要
- 采用生物测定级联灌流技术研究人脐静脉内皮衍生舒张因子（EDRF）的特性，并比较其对脐、绒毛板和牛肺动脉条的作用。2. 组胺（1微摩尔）、缓激肽（1微摩尔）和A-23187（0.3微摩尔、1微摩尔）可释放EDRF，但乙酰胆碱（1微摩尔）不能。3. 无神经支配的人胎儿胎盘血管，即脐动脉和绒毛板动脉，确实通过鸟苷3':5'-环磷酸（环鸟苷酸）介导的机制对EDRF产生舒张反应。4. 人脐动脉条对EDRF的敏感性低于绒毛板动脉条。牛肺动脉条对人脐EDRF的舒张作用最敏感。
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