Kerse Ngaire, Falloon Karen, Moyes Simon A, Hayman Karen J, Dowell Tony, Kolt Gregory S, Elley C Raina, Hatcher Simon, Peri Kathy, Keeling Sally, Robinson Elizabeth, Parsons John, Wiles Janine, Arroll Bruce
Department of General Practice and Primary Health Care, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
BMC Geriatr. 2008 May 24;8:12. doi: 10.1186/1471-2318-8-12.
Physical activity shows potential in combating the poor outcomes associated with depression in older people. Meta-analyses show gaps in the research with poor trial design compromising certainty in conclusions and few programmes showing sustained effects.
METHODS/DESIGN: The Depression in Late Life: an Intervention Trial of Exercise (DeLLITE) is a 12 month randomised controlled trial of a physical activity intervention to increase functional status in people aged 75 years and older with depressive symptoms. The intervention involves an individualised activity programme based on goal setting and progression of difficulty of activities delivered by a trained nurse during 8 home visits over 6 months. The control group received time matched home visits to discuss social contacts and networks. Baseline, 6 and 12 months measures were assessed in face to face visits with the primary outcome being functional status (SPPB, NEADL). Secondary outcomes include depressive symptoms (Geriatric Depression Scale), quality of life (SF-36), physical activity (AHS Physical Activity Questionnaire) and falls (self report).
Due to report in 2008 the DeLLITE study has recruited 70% of those eligible and tests the efficacy of a home based, goal setting physical activity programme in improving function, mood and quality of life in older people with depressive symptomatology. If successful in improving function and mood this trial could prove for the first time that there are long term health benefit of physical activity, independent of social activity, in this high risk group who consume excess health related costs.
Australian and New Zealand Clinical Trials Register ACTRN12605000475640.
体育活动在对抗老年人抑郁症相关不良后果方面显示出潜力。荟萃分析表明，研究存在差距，试验设计不佳影响了结论的确定性，且很少有项目显示出持续效果。
方法/设计：晚年抑郁症：运动干预试验（DeLLITE）是一项为期12个月的随机对照试验，旨在对一项体育活动干预措施进行研究，以提高75岁及以上有抑郁症状人群的功能状态。干预措施包括一个基于目标设定和活动难度递进的个性化活动项目，由一名经过培训的护士在6个月内进行8次家访时实施。对照组接受时间匹配的家访，以讨论社交联系和网络。在面对面家访中评估基线、6个月和12个月的测量指标，主要结局为功能状态（简短体能状况量表、日常活动能力量表）。次要结局包括抑郁症状（老年抑郁量表）、生活质量（健康调查简表）、体育活动（AHS体育活动问卷）和跌倒（自我报告）。
由于2008年的报告，DeLLITE研究已招募了70%符合条件的参与者，并测试了一项基于家庭、设定目标的体育活动项目在改善有抑郁症状老年人的功能、情绪和生活质量方面的疗效。如果该项目在改善功能和情绪方面取得成功，那么这项试验将首次证明，对于这个消耗过多与健康相关费用的高风险群体，体育活动具有独立于社交活动之外的长期健康益处。
澳大利亚和新西兰临床试验注册中心ACTRN12605000475640。
