拟南芥中的小RNA代谢
Small RNA metabolism in Arabidopsis.
作者信息
Ramachandran Vanitharani, Chen Xuemei
机构信息
Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
出版信息
Trends Plant Sci. 2008 Jul;13(7):368-74. doi: 10.1016/j.tplants.2008.03.008. Epub 2008 May 22.
Abstract
The Arabidopsis genome encodes two major classes of 20-24-nucleotide riboregulators: microRNAs and small interfering RNAs. These small RNAs act as sequence-specific repressors of target gene expression, either at the transcriptional level through DNA and/or histone methylation or at the post-transcriptional level through transcript cleavage or translational inhibition. Small RNAs are processed from precursor RNAs by one or more of the four DICER-LIKE RNase III enzymes, modified by HUA ENHANCER 1, a small RNA methyltransferase, and loaded onto an argonaute protein-containing RNA-induced silencing complex. Here, we review the biogenesis of small RNAs, and we discuss the major outstanding questions in small RNA metabolism and function.
摘要
拟南芥基因组编码两大类20 - 24个核苷酸的核糖调节因子：微小RNA和小干扰RNA。这些小RNA作为靶基因表达的序列特异性抑制因子，在转录水平通过DNA和/或组蛋白甲基化发挥作用，或在转录后水平通过转录本切割或翻译抑制发挥作用。小RNA由四种类似Dicer的核糖核酸酶III中的一种或多种从前体RNA加工而来，由小RNA甲基转移酶HUA增强子1修饰，并装载到含AGO蛋白的RNA诱导沉默复合体上。在此，我们综述小RNA的生物合成，并讨论小RNA代谢和功能方面的主要悬而未决的问题。
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