Krzystek-Korpacka Malgorzata, Patryn Eliza, Boehm Dorota, Berdowska Izabela, Zielinski Bogdan, Noczynska Anna
Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland.
Clin Biochem. 2008 Aug;41(12):943-9. doi: 10.1016/j.clinbiochem.2008.04.024. Epub 2008 May 10.
To evaluate the formation of advanced oxidation protein products (AOPPs) in juvenile overweight/obesity and obesity-related disorders and to investigate the effect of weight reduction on AOPPs.
AOPPs were determined in 114 overweight/obese children and adolescents without/with insulin resistance and metabolic syndrome and compared with 53 lean controls. Measurements were repeated following weight reduction program (diet/exercise, bran-enriched diet/exercise, and diet/exercise plus metformin).
Overweight/obese subjects had higher AOPPs than lean controls, more elevated in patients with co-occurring metabolic syndrome. AOPPs positively correlated with central obesity, triglycerides, lipid peroxidation and insulin, and negatively with glucose to insulin ratio. AOPPs decreased following obesity intervention and DeltaAOPPs correlated with DeltaBMI%. AOPPs reduction was more pronounced in subjects on bran-enriched diet. Baseline AOPPs were a better predictor of clinically significant weight reduction than BMI%.
Juvenile overweight/obesity was associated with AOPPs accumulation, more pronounced in metabolic syndrome. Body mass reduction decreased oxidative stress, with bran-enriched diet being more effective than diet/exercise alone.
评估青少年超重/肥胖及肥胖相关疾病中晚期氧化蛋白产物（AOPPs）的形成，并研究体重减轻对AOPPs的影响。
测定114名无/有胰岛素抵抗及代谢综合征的超重/肥胖儿童和青少年的AOPPs，并与53名瘦对照组进行比较。在体重减轻计划（饮食/运动、富含麸皮饮食/运动以及饮食/运动加二甲双胍）后重复测量。
超重/肥胖受试者的AOPPs高于瘦对照组，在同时患有代谢综合征的患者中升高更明显。AOPPs与中心性肥胖、甘油三酯、脂质过氧化和胰岛素呈正相关，与血糖胰岛素比值呈负相关。肥胖干预后AOPPs降低，且AOPPs的变化量与体重指数变化百分比（DeltaBMI%）相关。在富含麸皮饮食的受试者中，AOPPs的降低更为明显。基线AOPPs比体重指数百分比更能预测临床上显著的体重减轻。
青少年超重/肥胖与AOPPs积累有关，在代谢综合征中更为明显。体重减轻可降低氧化应激，富含麸皮饮食比单纯饮食/运动更有效。
