Münzberg Heike
Division of Metabolism, Endocrinology and Diabetes, Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Physiol Behav. 2008 Aug 6;94(5):664-9. doi: 10.1016/j.physbeh.2008.04.020. Epub 2008 Apr 22.
Leptin target sites are found in several hypothalamic areas with dense populations of long form leptin receptor (LepRb) expressing neurons which mediate important leptin actions. Leptin action has been most intensely investigated in the arcuate nucleus of the hypothalamus (ARC), which represents an important leptin target site. Recent data have shown that non-ARC leptin target sites mediate important aspects of leptin action, however, including the regulation of energy balance. Therefore, the investigation of discrete leptin signaling systems and their interactions will be an important step to understand the homeostatic action of leptin. In this review I discuss our recent data investigating important differences in leptin accessibility to ARC neurons in contrast to other hypothalamic sites like the dorsomedial hypothalamus (DMH) and discuss their importance for the leptin signaling system.
瘦素的靶位点存在于下丘脑的几个区域，这些区域有大量表达长型瘦素受体（LepRb）的神经元，它们介导重要的瘦素作用。瘦素作用在下丘脑弓状核（ARC）中得到了最深入的研究，ARC是一个重要的瘦素靶位点。然而，最近的数据表明，非ARC瘦素靶位点也介导瘦素作用的重要方面，包括能量平衡的调节。因此，研究离散的瘦素信号系统及其相互作用将是理解瘦素稳态作用的重要一步。在这篇综述中，我讨论了我们最近的数据，这些数据研究了与其他下丘脑位点（如下丘脑背内侧核（DMH））相比，瘦素进入ARC神经元的重要差异，并讨论了它们对瘦素信号系统的重要性。
