Borsonelo E C, Galduróz J C F
Department of Psychobiology, Federal University of São Paulo, Rua Botucatu 862, São Paulo, Brazil.
Prostaglandins Leukot Essent Fatty Acids. 2008 Apr-May;78(4-5):237-45. doi: 10.1016/j.plefa.2008.03.005. Epub 2008 May 27.
The polyunsaturated fatty acids (PUFAs), especially omega-3 and -6, play an important role in the functioning of membranes. Therefore, changes in their physical properties might entail impairment of the neurotransmission between cells. Studies emphasize the importance of omega-3 intakes, but they also highlight the need of a balance between omega-6 and -3, whose ideal ratio should be 4:1. The Western diet has very high amounts of saturated fat and omega-6, which might contribute, at least partially, to physiopathologies and high incidence as well as prevalence of psychiatric and neurodegenerative diseases. This narrow review aimed at systematizing the studies on the importance of PUFAs in some particular cases, that is, the extremes of life: pre- and post-natal development, and cognitive aging. Additionally, it aimed at studying the association between PUFAs and substance abuse disorders. We used the databases LILACs, MEDLINE and PUBMED.
多不饱和脂肪酸（PUFAs），尤其是ω-3和ω-6脂肪酸，在细胞膜功能中发挥着重要作用。因此，它们物理性质的改变可能会导致细胞间神经传递受损。研究强调了摄入ω-3脂肪酸的重要性，但也突出了ω-6和ω-3脂肪酸平衡的必要性，其理想比例应为4:1。西方饮食中饱和脂肪和ω-6脂肪酸含量很高，这可能至少部分地导致了生理病理学以及精神和神经退行性疾病的高发病率和高患病率。这篇简短综述旨在系统整理关于PUFAs在某些特定情况下重要性的研究，即生命的两端：产前和产后发育以及认知衰老。此外，它旨在研究PUFAs与物质使用障碍之间的关联。我们使用了LILACs、MEDLINE和PUBMED数据库。
