Department of Pharmacology and Toxicology and the University of Toronto Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, Canada.
Epilepsia. 2010 Aug;51(8):1348-58. doi: 10.1111/j.1528-1167.2010.02654.x. Epub 2010 Jul 1.
Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are dietary fatty acids that are involved in a myriad of physiologic processes in the brain. There is some evidence suggesting that PUFAs-and particularly omega-3 PUFAs-may have anticonvulsant effects, both in humans and in animals. In the present review, we assess the evidence related to the antiseizure properties of the n-3 PUFAs, discuss their possible mechanism(s) of action, and make recommendations for future clinical trials. In general, the available data from cell cultures and whole animal studies support the idea that the n-3 PUFAs have antiseizure properties. Future clinical trials involving the n-3 PUFAs should involve higher doses and longer periods of administration in order to definitively assess their possible antiseizure effects.
ω-3 和 ω-6 多不饱和脂肪酸（PUFAs）是膳食脂肪酸，它们参与大脑中的多种生理过程。有一些证据表明，PUFAs——特别是 ω-3 PUFAs——可能具有抗惊厥作用，无论是在人类还是动物中。在本综述中，我们评估了与 n-3 PUFAs 的抗惊厥特性相关的证据，讨论了它们可能的作用机制，并为未来的临床试验提出了建议。一般来说，来自细胞培养和整体动物研究的现有数据支持 n-3 PUFAs 具有抗惊厥特性的观点。涉及 n-3 PUFAs 的未来临床试验应使用更高的剂量和更长的给药时间，以明确评估它们可能的抗惊厥作用。
