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嗜肺军团菌与一种自由生活的变形虫（卡氏棘阿米巴）之间的温度依赖性寄生关系。

Temperature-dependent parasitic relationship between Legionella pneumophila and a free-living amoeba (Acanthamoeba castellanii).

作者信息

Ohno Akira, Kato Naoyuki, Sakamoto Ryota, Kimura Soichiro, Yamaguchi Keizo

机构信息

Department of Microbiology and Infectious Disease, Faculty of Medicine, Toho University, 5-21-16 Omori-Nishi, Ota-Ku, Tokyo 143-8540, Japan.

出版信息

Appl Environ Microbiol. 2008 Jul;74(14):4585-8. doi: 10.1128/AEM.00083-08. Epub 2008 May 23.

DOI:10.1128/AEM.00083-08
PMID:18502936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2493147/
Abstract

We analyzed the effects of temperature on the interaction of Legionella pneumophila with Acanthamoeba castellanii. At <20 degrees C, overexpression of type 1 metacaspase, a stimulator of A. castellanii encystation, was associated with a reduced number of bacteria within amoeba. At low temperatures, A. castellanii seems to eliminate L. pneumophila by encystation and digestion.

摘要

我们分析了温度对嗜肺军团菌与卡氏棘阿米巴相互作用的影响。在低于20摄氏度时，1型metacaspase（卡氏棘阿米巴包囊化的刺激因子）的过表达与阿米巴内细菌数量减少有关。在低温下，卡氏棘阿米巴似乎通过包囊化和消化来清除嗜肺军团菌。

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本文引用的文献

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The response regulator PmrA is a major regulator of the icm/dot type IV secretion system in Legionella pneumophila and Coxiella burnetii.应答调节因子PmrA是嗜肺军团菌和伯纳特立克次体中icm/dot IV型分泌系统的主要调节因子。
Mol Microbiol. 2007 Mar;63(5):1508-23. doi: 10.1111/j.1365-2958.2007.05604.x.
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Legionella prevalence in hot spring recreation areas of Taiwan.台湾温泉游乐区中军团菌的流行情况。
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A type-1 metacaspase from Acanthamoeba castellanii.来自卡氏棘阿米巴的1型 metacaspase。
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A community outbreak of Legionnaires' disease: evidence of a cooling tower as the source.军团病的社区暴发：冷却塔作为传染源的证据。
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Differentiate to thrive: lessons from the Legionella pneumophila life cycle.分化以求生存：嗜肺军团菌生命周期的启示
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Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosome.Dot/Icm 毒力系统对caspase-3的激活对于含军团菌吞噬体生物合成的停滞至关重要。
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Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication.嗜肺军团菌CsrA是传播特性的关键阻遏物和复制的激活物。
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