Iwatsuki Masato, Uchida Ryuji, Yoshijima Hitomi, Ui Hideaki, Shiomi Kazuro, Kim Yong-Pil, Hirose Tomoyasu, Sunazuka Toshiaki, Abe Akio, Tomoda Hiroshi, Omura Satoshi
The Kitasato Institute, Japan.
J Antibiot (Tokyo). 2008 Apr;61(4):230-6. doi: 10.1038/ja.2008.33.
The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. K01-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C(1), C(2) and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety.
胍迪诺霉素是由链霉菌属菌株K01 - 0509产生的一种新型细菌III型分泌系统抑制剂，通过包括各种核磁共振实验在内的光谱学研究阐明了其结构。胍迪诺霉素A、B、C(1)、C(2)和D共同由一个氨甲酰化的环状胍基部分、一个烷基链部分和一个L - 丙氨酰 - L - 缬氨酸部分组成，而胍迪诺酸是一个较小的分子，由一个氨甲酰化的环状胍基部分和一个羟基己酸部分组成。
