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口服α-生育酚一年对血液透析患者抗氧化防御系统的影响。

Effect of one-year oral alpha-tocopherol administration on the antioxidant defense system in hemodialysis patients.

作者信息

Antoniadi Georgia, Eleftheriadis Theodoros, Liakopoulos Vassilios, Kakasi Eleni, Kartsios Charalambos, Passadakis Ploumis, Vargemezis Vassilis

机构信息

Department of Nephrology, General Hospital of Serres, Serres, Greece.

出版信息

Ther Apher Dial. 2008 Jun;12(3):237-42. doi: 10.1111/j.1744-9987.2008.00580.x.

Abstract

Oxidative stress is increased in hemodialysis (HD) patients and contributes to the increased morbidity and mortality in this population. Vitamin E is an antioxidant agent. In the present study the effect of prolonged oral alpha-tocopherol administration on the antioxidant defense system was evaluated. The antioxidant factors plasma total antioxidant status (TAS), red blood cell superoxide dismutase (SOD) activity and glutathione peroxidase (GPX) activity were evaluated with spectrometry in 27 HD patients. Measurements were performed before and after oral administration of alpha-tocopherol at a dose of 500 mg/d for a one-year period. Twenty HD patients received a placebo and 22 healthy volunteers served as controls. TAS was increased in HD patients. No difference was detected in SOD and GPX activity between HD patients and healthy volunteers. Tocopherol administration induced a significant decrease in TAS and SOD activity. Levels of GPX activity remained unaffected. All the evaluated factors remained stable in the HD patients receiving a placebo. Prolonged oral alpha-tocopherol administration in HD patients induces a decrease in some components of the antioxidant defense system, raising the possibility for a pro-oxidative role of vitamin E. Vitamin E is an antioxidant agent, but it is also known to have pro-oxidant action under special conditions that can be encountered in HD patients.

摘要

血液透析(HD)患者的氧化应激增加,这导致了该人群发病率和死亡率的上升。维生素E是一种抗氧化剂。在本研究中,评估了长期口服α-生育酚对抗氧化防御系统的影响。采用光谱法对27例HD患者的抗氧化因子血浆总抗氧化状态(TAS)、红细胞超氧化物歧化酶(SOD)活性和谷胱甘肽过氧化物酶(GPX)活性进行了评估。在口服剂量为500mg/d的α-生育酚一年前后进行测量。20例HD患者接受安慰剂,22名健康志愿者作为对照。HD患者的TAS升高。HD患者与健康志愿者之间的SOD和GPX活性未检测到差异。生育酚给药导致TAS和SOD活性显著降低。GPX活性水平未受影响。接受安慰剂的HD患者中所有评估因素均保持稳定。HD患者长期口服α-生育酚会导致抗氧化防御系统的某些成分减少,这增加了维生素E具有促氧化作用的可能性。维生素E是一种抗氧化剂,但在HD患者可能遇到的特殊条件下,它也具有促氧化作用。

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