鼻炎病程与鼻腔功能恶化之间的关系。
Relationship between rhinitis duration and worsening of nasal function.
作者信息
Ciprandi Giorgio, Cirillo Ignazio, Pistorio Angela, La Grutta Stefania
机构信息
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy.
出版信息
Otolaryngol Head Neck Surg. 2008 Jun;138(6):725-9. doi: 10.1016/j.otohns.2008.03.027.
BACKGROUND
While it is well known that asthma is characterized by airway remodeling, few studies instead have investigated this issue in patients with allergic rhinitis (AR).
OBJECTIVE
The aim of the study was to evaluate nasal function, ie, nasal airflow, in a cohort of patients with persistent AR (PER).
METHODS
One hundred patients, 50 with short-term and 50 with long-term PER, were prospectively and consecutively evaluated, clinically evaluated by visit, skin prick test, and rhinomanometry.
RESULTS
Nasal airflow values were significantly lower (median flow: 348 mL/sec) in patients with long-term rhinitis (median duration nine years) as compared to patients with short-term (median duration one year) rhinitis (median flow: 466 mL/sec) (P < 0.0001).
CONCLUSION
This study provides the first evidence that patients with PER may show a progressive worsening of nasal airflow depending on the duration of the disorder.
背景
虽然众所周知哮喘的特征是气道重塑，但相反，很少有研究在过敏性鼻炎（AR）患者中调查这个问题。
目的
本研究的目的是评估一组持续性AR（PER）患者的鼻腔功能，即鼻气流。
方法
前瞻性地连续评估了100例患者，其中50例为短期PER患者，50例为长期PER患者，通过就诊、皮肤点刺试验和鼻阻力测量进行临床评估。
结果
与短期（中位病程1年）鼻炎患者（中位流量：466毫升/秒）相比，长期（中位病程9年）鼻炎患者的鼻气流值显著更低（中位流量：348毫升/秒）（P < 0.0001）。
结论
本研究提供了首个证据，表明PER患者的鼻气流可能会根据疾病持续时间而逐渐恶化。
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