电压门控钠通道的选择性：保守结构域III赖氨酸残基的作用。 - Suppr

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超能文献

Voltage-gated Na channel selectivity: the role of the conserved domain III lysine residue.

作者信息

Lipkind Gregory M, Fozzard Harry A

机构信息

Cardiac Electrophysiology Laboratories Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

出版信息

J Gen Physiol. 2008 Jun;131(6):523-9. doi: 10.1085/jgp.200809991.

DOI:10.1085/jgp.200809991

PMID:18504313

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2391246/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1f2/2391246/17fc22ea1937/jgp1310523f01.jpg

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Tuning ion coordination architectures to enable selective partitioning.调整离子配位结构以实现选择性分配。

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Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.利多卡因结合位点残基苯丙氨酸-1759处的电荷变化影响人类心脏电压门控钠通道的通透性。

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