Huwart Laurent, Salameh Najat, ter Beek Leon, Vicaut Eric, Peeters Frank, Sinkus Ralph, Van Beers Bernard E
Diagnostic Radiology Unit, Université Catholique de Louvain, St-Luc University Hospital, Brussels, Belgium.
Eur Radiol. 2008 Nov;18(11):2535-41. doi: 10.1007/s00330-008-1051-5. Epub 2008 May 27.
The purpose of this study was to prospectively compare the performance of magnetic resonance (MR) elastography using echo-planar and spin-echo imaging for staging of hepatic fibrosis. Twenty-four patients who had liver biopsy for suspicion of chronic liver disease had MR elastography performed with both spin-echo and echo-planar sequences. At histology, the fibrosis stage was assessed according to METAVIR. The data acquisition time was about 20 min using spin-echo, and only 2 min using echo-planar imaging. The hepatic signal-to-noise ratios were similar on both images (22.51 +/- 5.37 for spin-echo versus 21.02 +/- 4.76 for echo-planar, p = 0.33). The elasticity measurements and the fibrosis stages were strongly correlated. The Spearman correlation coefficients were r = 0.91 (p < 0.01) with spin-echo and r = 0.84 (p < 0.01) with echo-planar sequences. These correlation coefficients did not differ significantly (p = 0.17). A strong correlation was also observed between spin-echo and echo-planar elasticity (r = 0.83, p < 0.001), without systematic bias. The results of our study showed that echo-planar imaging substantially decreased the data acquisition time of MR elastography, while maintaining the image quality and diagnostic performance for staging of liver fibrosis. This suggests that echo-planar MR elastography could replace spin-echo MR elastography in clinical practice.
本研究的目的是前瞻性比较使用回波平面成像和自旋回波成像的磁共振弹性成像在肝纤维化分期中的表现。24例因怀疑患有慢性肝病而接受肝活检的患者接受了自旋回波和回波平面序列的磁共振弹性成像检查。在组织学检查中，根据METAVIR评估纤维化分期。使用自旋回波时数据采集时间约为20分钟，而使用回波平面成像时仅为2分钟。两幅图像上的肝脏信噪比相似（自旋回波为22.51±5.37，回波平面为21.02±4.76，p = 0.33）。弹性测量值与纤维化分期密切相关。自旋回波的Spearman相关系数为r = 0.91（p < 0.01），回波平面序列为r = 0.84（p < 0.01）。这些相关系数无显著差异（p = 0.17）。自旋回波和回波平面弹性之间也观察到强相关性（r = 0.83，p < 0.001），且无系统偏差。我们的研究结果表明，回波平面成像在保持肝纤维化分期的图像质量和诊断性能的同时，显著缩短了磁共振弹性成像的数据采集时间。这表明在临床实践中，回波平面磁共振弹性成像可以取代自旋回波磁共振弹性成像。
