溶血磷脂酸（LPA）与血管生成
Lysophosphatidic acid (LPA) and angiogenesis.
作者信息
Rivera-Lopez Carol M, Tucker Amy L, Lynch Kevin R
机构信息
Department of Pharmacology, University of Virginia, School of Medicine, Box 800735, 1340 Jefferson Park Avenue, Charlottesville, VA 22903-0735, USA.
出版信息
Angiogenesis. 2008;11(3):301-10. doi: 10.1007/s10456-008-9113-5. Epub 2008 May 27.
Abstract
Lysophosphatidic acid (LPA) is a simple lipid with many important biological functions such as the regulation of cellular proliferation, cellular migration, differentiation, and suppression of apoptosis. Although a direct angiogenic effect of LPA has not been reported to date, there are indications that LPA promotes angiogenesis. In addition, LPA is a chemoattractant for cultured endothelial cells and promotes barrier function in such cultures. To test the hypothesis that LPA is angiogenic, we used the chicken chorio-allantoic membrane (CAM) assay. Sequence analysis of the cloned, full-length chicken LPA receptor cDNAs revealed three receptor types that are orthologous to the mammalian LPA(1), LPA(2), and LPA(3) receptors. We document herein that LPA is angiogenic in the CAM system and further that synthetic LPA receptor agonists and antagonists mimic or block this response, respectively. Our results predict that LPA receptor antagonists are a possible therapeutic route to interdicting angiogenesis.
摘要
溶血磷脂酸（LPA）是一种简单的脂质，具有许多重要的生物学功能，如调节细胞增殖、细胞迁移、分化以及抑制细胞凋亡。尽管迄今为止尚未报道LPA有直接的血管生成作用，但有迹象表明LPA可促进血管生成。此外，LPA是培养的内皮细胞的趋化因子，并可促进此类培养物中的屏障功能。为了验证LPA具有血管生成作用这一假说，我们采用了鸡胚绒毛尿囊膜（CAM）试验。对克隆的全长鸡LPA受体cDNA进行序列分析，发现了三种与哺乳动物LPA(1)、LPA(2)和LPA(3)受体直系同源的受体类型。我们在此证明，LPA在CAM系统中具有血管生成作用，而且合成的LPA受体激动剂和拮抗剂分别模拟或阻断了这种反应。我们的结果预测，LPA受体拮抗剂可能是阻断血管生成的一种治疗途径。
相似文献
1
Lysophosphatidic acid (LPA) and angiogenesis.溶血磷脂酸（LPA）与血管生成
Angiogenesis. 2008;11(3):301-10. doi: 10.1007/s10456-008-9113-5. Epub 2008 May 27.
2
Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis.1-磷酸鞘氨醇诱导内皮细胞趋化作用，溶血磷脂酸稳定内皮单层屏障功能，二者可能是造血血管生成的介质。
J Hematother Stem Cell Res. 1999 Dec;8(6):627-34. doi: 10.1089/152581699319795.
3
Lysophosphatidic acid mediates interleukin-8 expression in human endometrial stromal cells through its receptor and nuclear factor-kappaB-dependent pathway: a possible role in angiogenesis of endometrium and placenta.溶血磷脂酸通过其受体和核因子-κB依赖性途径介导人子宫内膜基质细胞中白细胞介素-8的表达：在子宫内膜和胎盘血管生成中的可能作用。
Endocrinology. 2008 Nov;149(11):5888-96. doi: 10.1210/en.2008-0314. Epub 2008 Jul 10.
4
Lysophosphatidic acid up-regulates expression of interleukin-8 and -6 in granulosa-lutein cells through its receptors and nuclear factor-kappaB dependent pathways: implications for angiogenesis of corpus luteum and ovarian hyperstimulation syndrome.溶血磷脂酸通过其受体和核因子-κB依赖途径上调颗粒黄体细胞中白细胞介素-8和-6的表达：对黄体血管生成和卵巢过度刺激综合征的影响。
J Clin Endocrinol Metab. 2008 Mar;93(3):935-43. doi: 10.1210/jc.2007-1512. Epub 2008 Jan 2.
5
Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA(1/3), COX-2, and NF-kappaB activation- and EGFR transactivation-dependent mechanisms.溶血磷脂酸通过LPA(1/3)、COX-2和NF-κB激活以及EGFR反式激活依赖性机制上调人内皮细胞中的血管内皮生长因子C并促进其管腔形成。
Cell Signal. 2008 Oct;20(10):1804-14. doi: 10.1016/j.cellsig.2008.06.008. Epub 2008 Jun 21.
6
Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells.鞘氨醇-1-磷酸和溶血磷脂酸对内皮细胞的不同作用。
Biochim Biophys Acta. 2002 May 23;1582(1-3):190-6. doi: 10.1016/s1388-1981(02)00155-5.
7
Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms.生物活性脂质溶血磷脂酸和鞘氨醇 1-磷酸通过不同的机制介导乳腺癌细胞的生物学功能。
Oncol Res. 2009;18(4):173-84. doi: 10.3727/096504009790217399.
8
Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expression.溶血磷脂酸通过调节Gi/核因子-κB依赖性血管生成因子的表达来增强人软骨细胞的血管生成能力。
PLoS One. 2014 May 30;9(5):e95180. doi: 10.1371/journal.pone.0095180. eCollection 2014.
9
Lysophosphatidic acid up-regulates expression of growth-regulated oncogene-alpha, interleukin-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts: possible roles in angiogenesis and immune regulation.溶血磷脂酸上调人早孕绒毛滋养层细胞生长调节癌基因-α、白细胞介素-8 和单核细胞趋化蛋白-1 的表达：在血管生成和免疫调节中的可能作用。
Endocrinology. 2010 Jan;151(1):369-79. doi: 10.1210/en.2009-0779. Epub 2009 Nov 11.
10
Effects of lysophosphatidic acid and its receptors LPA⅓ on radiation pneumonitis.溶血磷脂酸及其受体 LPAⅢ对放射性肺炎的影响。
Oncol Rep. 2010 Dec;24(6):1515-20. doi: 10.3892/or_00001013.
引用本文的文献
1
High expression of ENPP2 is an independent predictor of poor prognosis in liver cancer.ENPP2 高表达是肝癌预后不良的独立预测因子。
Medicine (Baltimore). 2023 Aug 4;102(31):e34480. doi: 10.1097/MD.0000000000034480.
2
Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.基于内源性别构调节剂的新型类自主分泌酶抑制剂的结构设计。
J Med Chem. 2022 Apr 28;65(8):6338-6351. doi: 10.1021/acs.jmedchem.2c00368. Epub 2022 Apr 20.
3
Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases.肠道脂肪：炎症性肠病中的上皮磷脂。
Int J Mol Sci. 2021 Oct 28;22(21):11682. doi: 10.3390/ijms222111682.
4
Effect of Lysophosphatidic Acid on the Vascular Endothelial Growth Factor Expression in Autotransplanted Mouse Ovaries Encapsulated in Sodium Alginate.溶血磷脂酸对藻酸钠包封的自体移植小鼠卵巢中血管内皮生长因子表达的影响
J Family Reprod Health. 2021 Jun;15(2):91-98. doi: 10.18502/jfrh.v15i2.6449.
5
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.强效选择性非锌结合自分泌运动因子抑制剂BIO-32546的发现
ACS Med Chem Lett. 2021 Jun 14;12(7):1124-1129. doi: 10.1021/acsmedchemlett.1c00211. eCollection 2021 Jul 8.
6
The LPA Receptor: Regulation and Activation of Signaling Pathways.LPA 受体：信号通路的调节和激活。
Int J Mol Sci. 2021 Jun 23;22(13):6704. doi: 10.3390/ijms22136704.
7
Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe/PSEN-1 double-transgenic mouse model of Αlzheimer's disease.人参红景天苷减轻阿尔茨海默病APPswe/PSEN-1双转基因小鼠模型中脑微血管通透性和微血管内皮连接蛋白的破坏。
Exp Ther Med. 2021 Apr;21(4):310. doi: 10.3892/etm.2021.9741. Epub 2021 Feb 1.
8
Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion Mechanisms Similar and Distinct From CTLA-4 and PD-1.溶血磷脂酸是一种炎症脂质，癌症利用它来逃避免疫机制，与 CTLA-4 和 PD-1 相似但又有所不同。
Front Immunol. 2021 Jan 27;11:531910. doi: 10.3389/fimmu.2020.531910. eCollection 2020.
9
Angiogenesis Inhibition in Prostate Cancer: An Update.前列腺癌中的血管生成抑制：最新进展
Cancers (Basel). 2020 Aug 23;12(9):2382. doi: 10.3390/cancers12092382.
10
Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration.生物活性脂质信号在心血管疾病、发育和再生中的作用。
Cells. 2020 Jun 3;9(6):1391. doi: 10.3390/cells9061391.
本文引用的文献
1
Angiogenesis: an organizing principle for drug discovery?血管生成：药物发现的一个组织原则？
Nat Rev Drug Discov. 2007 Apr;6(4):273-86. doi: 10.1038/nrd2115.
2
Plaque angiogenesis versus compensatory arteriogenesis in atherosclerosis.动脉粥样硬化中的斑块血管生成与代偿性动脉生成
Circ Res. 2006 Oct 13;99(8):787-9. doi: 10.1161/01.RES.0000247758.34085.a6.
3
Targeting sphingosine-1-phosphate for cancer therapy.靶向鞘氨醇-1-磷酸用于癌症治疗。
Br J Cancer. 2006 Nov 6;95(9):1131-5. doi: 10.1038/sj.bjc.6603400. Epub 2006 Oct 3.
4
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.自分泌运动因子，一种分泌型溶血磷脂酶D，在发育过程中对血管形成至关重要。
Mol Cell Biol. 2006 Jul;26(13):5015-22. doi: 10.1128/MCB.02419-05.
5
GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5.GPR92作为一种新的与G12/13和Gq偶联的溶血磷脂酸受体，即LPA5，可增加环磷酸腺苷（cAMP）。
J Biol Chem. 2006 Aug 18;281(33):23589-97. doi: 10.1074/jbc.M603670200. Epub 2006 Jun 14.
6
Angiogenesis in life, disease and medicine.生命、疾病与医学中的血管生成
Nature. 2005 Dec 15;438(7070):932-6. doi: 10.1038/nature04478.
7
Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA).棕色遁蛛（褐蛛）毒液中的磷脂酶D（PLD）可生成溶血磷脂酸（LPA）。
Biochem J. 2005 Oct 15;391(Pt 2):317-23. doi: 10.1042/BJ20050043.
8
Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells.溶血磷脂增强人内皮细胞中基质金属蛋白酶-2的表达。
Endocrinology. 2005 Aug;146(8):3387-400. doi: 10.1210/en.2004-1654. Epub 2005 May 5.
9
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing.LPA3介导的溶血磷脂酸信号传导在胚胎植入和间隔中的作用
Nature. 2005 May 5;435(7038):104-8. doi: 10.1038/nature03505.
10
Lysophospholipids in development: Miles apart and edging in.发育过程中的溶血磷脂：相距甚远且逐渐靠近。
J Cell Biochem. 2004 Aug 1;92(5):967-92. doi: 10.1002/jcb.20128.
Zotero 插件