Park Jeong A, Ha Sang Keun, Kang Tong Ho, Oh Myung Sook, Cho Min Hyoung, Lee Soo Yeol, Park Ji-Ho, Kim Sun Yeou
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, #1 Seocheon-dong, Kihung-ku, Yongin-City, Kyungki-Do 449-701, South Korea.
Life Sci. 2008 Jun 20;82(25-26):1217-23. doi: 10.1016/j.lfs.2008.03.021. Epub 2008 Apr 10.
Recent studies have shown that apigenin not only inhibits bone resorption by osteoclasts but also induces osteoclast apoptosis. However, the influence of apigenin on osteoporosis in animals is relatively unknown. The purpose of this study was to examine the bone-protective effects of apigenin in estrogen-deficient ovariectomized rats. Three-month-old female Sprague-Dawley rats were either sham-operated or ovariectomized and fed AIN-93G diet for 7 weeks to induce bone loss. To confirm bone loss, we used a newly developed non-invasive technique involving zoom-in micro-computed tomography. Apigenin was administered at a dose of 10 mg/kg three times a week for 15 weeks. Our results indicate that apigenin not only increased the mineral content and density of the trabecular bone at the neck of the left femur, but also decreased body weight and dietary consumption. Moreover, our biochemical results indicate that apigenin has a positive effect on bone turnover. The present data suggest that apigenin should be considered for use in the treatment of osteoporosis.
最近的研究表明，芹菜素不仅能抑制破骨细胞的骨吸收，还能诱导破骨细胞凋亡。然而，芹菜素对动物骨质疏松症的影响相对未知。本研究的目的是检测芹菜素对雌激素缺乏的去卵巢大鼠的骨骼保护作用。将3个月大的雌性斯普拉格-道利大鼠进行假手术或去卵巢手术，并喂食AIN-93G饮食7周以诱导骨质流失。为了确认骨质流失，我们使用了一种新开发的涉及放大微计算机断层扫描的非侵入性技术。芹菜素以10毫克/千克的剂量每周给药3次，持续15周。我们的结果表明，芹菜素不仅增加了左股骨颈小梁骨的矿物质含量和密度，还降低了体重和饮食摄入量。此外，我们的生化结果表明，芹菜素对骨转换有积极作用。目前的数据表明，芹菜素应被考虑用于治疗骨质疏松症。
