Isawa T, Teshima T, Anazawa Y, Miki M, Motomiya M
Department of Medicine, Tohoku University, Sendai, Japan.
Nucl Med Commun. 1991 Jan;12(1):47-55. doi: 10.1097/00006231-199101000-00006.
Technegas, an aerosol generator recently devised in Australia, produces aerosol particulates called 'technegas' which have characteristics of both an aerosol and a gas. The majority of the particulate is below 200 nm in size as measured by electron microscopy. Four normal subjects and 31 patients with various lung diseases were studied by imaging the lungs following inhalation of technegas. The penetration of inhaled technegas to the lung periphery was excellent; the average alveolar deposition ratio (ALDR) was 85%. Comparative studies with lung images obtained either with an ultrasonic nebulizer or jet nebulizers also confirmed better penetration of inhaled technegas to the lung periphery. There was no significant statistical difference in the ALDRs between normals and patients. Aerosol studies were comparable to perfusion counterparts, and evaluation of regional ventilatory status was greatly facilitated. Because of the large ALDR and the low airway deposition ratio (ADR), actual imaging could be done not only immediately after aerosol inhalation but also some time later without losing too much radioactivity from the lungs. One disadvantage was that technegas immediately after generation was anoxic.
技术气体（Technegas）是澳大利亚最近研制的一种气溶胶发生器，它能产生一种名为“技术气体”的气溶胶颗粒，这种颗粒兼具气溶胶和气体的特性。通过电子显微镜测量，大部分颗粒的尺寸在200纳米以下。对4名正常受试者和31名患有各种肺部疾病的患者在吸入技术气体后进行肺部成像研究。吸入的技术气体向肺周边的渗透情况良好；平均肺泡沉积率（ALDR）为85%。与使用超声雾化器或喷射雾化器获得的肺部图像进行的对比研究也证实，吸入的技术气体向肺周边的渗透更好。正常人与患者之间的肺泡沉积率没有显著的统计学差异。气溶胶研究与灌注研究相当，极大地促进了对局部通气状态的评估。由于肺泡沉积率高且气道沉积率（ADR）低，不仅可以在气溶胶吸入后立即进行实际成像，而且在一段时间后也可以进行，而肺部不会损失太多放射性。一个缺点是，技术气体产生后立即处于缺氧状态。
