Dick J E
Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada.
Cancer Cells. 1991 Feb;3(2):39-48.
A complete understanding of the organization of the human hematopoietic stem cell hierarchy and of the molecular events regulating the stem cell developmental program has been hampered by the absence of suitable in vivo stem cell assays. Perturbations in the normal stem cell program that lead to neoplastic growth are also difficult to study because leukemic cells do not grow readily in culture. Recent advances in the transplantation of human cells into immune-deficient mice provide an unprecedented opportunity to study human hematopoiesis--both normal and abnormal--in the context of a small animal model. Here I review several of these new animal models and the basic concepts of murine and human hematopoiesis which led to their development.
由于缺乏合适的体内干细胞检测方法，对人类造血干细胞层级组织以及调控干细胞发育程序的分子事件的全面理解受到了阻碍。导致肿瘤生长的正常干细胞程序的紊乱也难以研究，因为白血病细胞在培养中不易生长。将人类细胞移植到免疫缺陷小鼠体内的最新进展为在小型动物模型中研究正常和异常的人类造血作用提供了前所未有的机会。在此，我将综述其中几种新的动物模型以及促成其发展的小鼠和人类造血作用的基本概念。
