Guan Zhiwei, Vgontzas Alexandros N, Bixler Edward O, Fang Jidong
Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Sleep. 2008 May;31(5):627-33. doi: 10.1093/sleep/31.5.627.
To determine whether weight loss could reverse excessive sleep in high-fat diet-induced obesity.
Three groups of mice participated in the study. A weight gain/loss group was fed with high-fat food for 6 weeks (weight gain), and regular food again for 4 weeks (weight loss). A control group and a weight gain only group were fed with regular food and high-fat food, respectively, for 10 weeks after the baseline.
Adult male C57BL/6 mice.
The amounts of wake, rapid eye movement sleep (REMS) and non-REM sleep (NREMS) were determined at week 0 (baseline), week 6, and week 10.
The weight gain/loss group displayed a significant decrease in wakefulness and increases in NREMS and episodes of NREMS during 6 weeks of weight gain, which were reversed during subsequent 4 weeks of weight loss. The weight gain only group displayed significant decrease in wakefulness and increase of NREMS and REMS at both week 6 and week 10. The control group did not show significant sleep alterations during the experiment.
These observations indicate that sleep alterations induced by weight gain are reversed by weight loss in obese animals. These data may shed light on the mechanisms underlying the well-established association between obesity and sleepiness in humans and may lead to new therapeutic strategies for these 2 increasingly prevalent problems in the modern societies.
确定体重减轻是否能逆转高脂饮食诱导肥胖中的过度睡眠。
三组小鼠参与了该研究。体重增减组先喂食高脂食物6周（体重增加），然后再喂食常规食物4周（体重减轻）。对照组和仅体重增加组在基线后分别喂食常规食物和高脂食物10周。
成年雄性C57BL/6小鼠。
在第0周（基线）、第6周和第10周测定清醒时间、快速眼动睡眠（REMS）和非快速眼动睡眠（NREMS）的时长。
体重增减组在体重增加的6周内清醒时间显著减少，NREMS时长及NREMS发作次数增加，而在随后体重减轻的4周内这些变化发生了逆转。仅体重增加组在第6周和第10周时清醒时间显著减少，NREMS和REMS增加。对照组在实验期间未表现出明显的睡眠改变。
这些观察结果表明，肥胖动物体重增加引起的睡眠改变可通过体重减轻而逆转。这些数据可能有助于揭示肥胖与人类嗜睡之间既定关联的潜在机制，并可能为现代社会中这两个日益普遍的问题带来新的治疗策略。
