Kearney Greg
Florida Department of Health, Division of Environmental Health, Tallahassee, FL 32399, USA.
J Environ Health. 2008 May;70(9):29-34; quiz 55-6.
Despite over 20 years of research on childhood cancer clusters and hazardous waste sites, little evidence has been produced to indicate a causal relationship. Nevertheless, the perception of a childhood cancer cluster being located near a hazardous waste site can raise fear and uncertainty, and it demands attention from health officials. To investigate this public health concern, the author used the spatial-scan statistical software SaTScan to detect childhood cancer clusters and their proximity to National Priority List (NPL), or Superfund, sites in Florida. In the ecological study reported here, "most likely" clusters were defined as those with a p-value of < .05. Distance served as a proxy for exposure; a geographical information system (GIS) was used to determine the number of clusters within a predetermined distance of an NPL site. Spatial clusters were found to occur randomly throughout the state, with most clusters being identified in the more populated counties, and clusters less likely to occur near an NPL site. This article attempts to explain the utility of an emerging public health surveillance tool for detecting cancer clusters near hazardous waste sites. Despite several epidemiological limitations of the study, as well as the fact that there are other environmental exposure hazards such as Toxic Release Inventory facilities and landfills, the SaTScan program proved useful as a surveillance tool for generating more in-depth studies.
尽管对儿童癌症聚集区和危险废物处理场进行了20多年的研究,但几乎没有证据表明两者之间存在因果关系。然而,人们认为儿童癌症聚集区位于危险废物处理场附近会引发恐惧和不确定性,这需要卫生官员予以关注。为了调查这一公共卫生问题,作者使用空间扫描统计软件SaTScan来检测佛罗里达州的儿童癌症聚集区及其与国家优先名录(NPL)或超级基金场地的距离。在此报告的生态研究中,“极有可能”的聚集区定义为p值小于0.05的区域。距离作为暴露的替代指标;利用地理信息系统(GIS)来确定在NPL场地预定距离内的聚集区数量。研究发现空间聚集区在该州随机出现,大多数聚集区出现在人口较多的县,且聚集区在NPL场地附近出现的可能性较小。本文试图解释一种新兴的公共卫生监测工具在检测危险废物处理场附近癌症聚集区方面的效用。尽管该研究存在一些流行病学局限性,以及存在其他环境暴露危害,如有毒物质排放清单设施和垃圾填埋场,但SaTScan程序被证明是一种有用的监测工具,可用于开展更深入的研究。