Ecker David J, Sampath Rangarajan, Massire Christian, Blyn Lawrence B, Hall Thomas A, Eshoo Mark W, Hofstadler Steven A
Ibis Biosciences, 1896 Rutherford Road, Carlsbad, California 92008, USA.
Nat Rev Microbiol. 2008 Jul;6(7):553-8. doi: 10.1038/nrmicro1918. Epub 2008 Jun 3.
We describe a new technology, the Ibis T5000, for the identification of pathogens in clinical and environmental samples. The Ibis T5000 couples nucleic acid amplification to high-performance electrospray ionization mass spectrometry and base-composition analysis. The system enables the identification and quantification of a broad set of pathogens, including all known bacteria, all major groups of pathogenic fungi and the major families of viruses that cause disease in humans and animals, along with the detection of virulence factors and antibiotic resistance markers.
我们描述了一种用于鉴定临床和环境样本中病原体的新技术——Ibis T5000。Ibis T5000将核酸扩增与高性能电喷雾电离质谱及碱基组成分析相结合。该系统能够鉴定和定量多种病原体，包括所有已知细菌、所有主要致病真菌类别以及在人类和动物中致病的主要病毒科，同时还能检测毒力因子和抗生素耐药性标志物。
