Darbes Lynae, Crepaz Nicole, Lyles Cynthia, Kennedy Gail, Rutherford George
Center for AIDS Prevention Studies and Global Health Sciences, University of California, San Francisco, CA 94105, USA.
AIDS. 2008 Jun 19;22(10):1177-94. doi: 10.1097/QAD.0b013e3282ff624e.
To conduct a meta-analytic review of HIV interventions for heterosexual African Americans to determine the overall efficacy in reducing HIV-risk sex behaviors and incident sexually transmitted diseases and identify intervention characteristics associated with efficacy.
Comprehensive searches included electronic databases from 1988 to 2005, handsearches of journals, reference lists of articles, and contacts with researchers. Thirty-eight randomized controlled trials met the selection criteria. Random-effects models were used to aggregate data.
Interventions significantly reduced unprotected sex (odds ratio = 0.75; 95% confidence interval = 0.67, 0.84; 35 trials; N = 14 682) and marginally significantly decreased incident sexually transmitted diseases (odds ratio = 0.88; 95% confidence interval = 0.72, 1.07; 10 trials; N = 10 944). Intervention characteristics associated with efficacy include cultural tailoring, aiming to influence social norms in promoting safe sex behavior, utilizing peer education, providing skills training on correct use of condoms and communication skills needed for negotiating safer sex, and multiple sessions and opportunities to practice learned skills.
Interventions targeting heterosexual African Americans are efficacious in reducing HIV-risk sex behaviors. Efficacious intervention components identified in this study should be incorporated into the development of future interventions and further evaluated for effectiveness.
对针对异性恋非裔美国人的艾滋病病毒干预措施进行荟萃分析综述,以确定在减少艾滋病病毒风险性行为和性传播疾病发病率方面的总体疗效,并确定与疗效相关的干预特征。
全面检索包括1988年至2005年的电子数据库、期刊手工检索、文章参考文献列表以及与研究人员的联系。38项随机对照试验符合入选标准。采用随机效应模型汇总数据。
干预措施显著减少了无保护性行为(优势比=0.75;95%置信区间=0.67,0.84;35项试验;N=14682),并在一定程度上显著降低了性传播疾病的发病率(优势比=0.88;95%置信区间=0.72,1.07;10项试验;N=10944)。与疗效相关的干预特征包括文化调适、旨在影响促进安全性行为的社会规范、利用同伴教育、提供正确使用避孕套的技能培训以及协商更安全性行为所需的沟通技能,以及多次课程和练习所学技能的机会。
针对异性恋非裔美国人的干预措施在减少艾滋病病毒风险性行为方面是有效的。本研究中确定的有效干预成分应纳入未来干预措施的开发中,并进一步评估其有效性。