Gupta Pawan, Sachdev Nishant, Kaur Jasleen, Dey Pranab, Gupta Vishali, Gupta Amod
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
Int Ophthalmol. 2009 Aug;29(4):315-8. doi: 10.1007/s10792-008-9235-1. Epub 2008 Jun 5.
Acute and invasive fungal infections are usually seen in immunocompromised and debilitated patients. We report a young immunocompetent 28-year-old Indian male who presented with unilateral endogenous endophthalmitis in the left eye and was managed with pars plana vitreous surgery. The polymerase chain reaction from the vitrectomy specimen tested positive for the fungal genome while the cytology examination identified aseptate hyphae with wide-angle branching, most likely suggesting Zygomycosis. A detailed systemic evaluation failed to reveal any systemic focus or predisposing factor for fungal infection. The patient had received intravenous dextrose infusions while undergoing a surgical procedure for post-traumatic hydrocele elsewhere a week prior to this episode. The patient was successfully managed with pars plana vitreous surgery along with intravitreal Amphotericin-B and oral Voriconazole.
急性和侵袭性真菌感染通常见于免疫功能低下和身体虚弱的患者。我们报告了一名28岁免疫功能正常的年轻印度男性，他左眼出现单侧内源性眼内炎，并接受了玻璃体切除术治疗。玻璃体切除标本的聚合酶链反应检测到真菌基因组呈阳性，而细胞学检查发现有宽角分支的无隔菌丝，最有可能提示为接合菌病。详细的全身评估未能发现任何真菌感染的全身病灶或易感因素。该患者在本次发病前一周，在其他地方接受创伤后鞘膜积液手术时接受了静脉输注葡萄糖。该患者通过玻璃体切除术联合玻璃体内注射两性霉素B和口服伏立康唑成功治愈。
