Jørgensen B B, Pedersen N T, Worning H
Medical Dept. F, Glostrup Hospital, Denmark.
Scand J Gastroenterol. 1991 Mar;26(3):321-6. doi: 10.3109/00365529109025049.
Twenty-three outpatients with chronic pancreatitis and severe exocrine insufficiency were studied for the purpose of comparing the effect of Pancrease, Pankreon, and Pankreatin by estimation of duodenal enzyme activity, the faecal fat excretion, and the faecal 14C-triolein-3H-oleic acid test and, at the same time, to evaluate these tests when monitoring outpatients. The three preparations did not disclose any significant difference in treating steatorrhoea. Pankreatin increased the meal-stimulated duodenal enzyme activity (p less than 0.01) and caused reduction in the faecal fat excretion (p less than 0.05), whereas no change in these variables were observed with Pankreon or Pancrease. The faecal 14C-triolein-3H-oleic acid test showed significant improvement in the 14C-triolein digestion with all three preparations (p less than 0.01). The faecal 14C-triolein-3H-oleic acid test was the most reliable when monitoring outpatients.
对23例患有慢性胰腺炎且有严重外分泌功能不全的门诊患者进行了研究，目的是通过评估十二指肠酶活性、粪便脂肪排泄以及粪便14C-三油酸甘油酯-3H-油酸试验来比较胰酶片、胰酶肠溶胶囊和胰酶的疗效，同时评估这些试验在监测门诊患者时的效果。这三种制剂在治疗脂肪泻方面未显示出任何显著差异。胰酶可增加进食刺激后的十二指肠酶活性（p<0.01），并使粪便脂肪排泄减少（p<0.05），而胰酶肠溶胶囊或胰酶片则未观察到这些变量的变化。粪便14C-三油酸甘油酯-3H-油酸试验显示，所有三种制剂的14C-三油酸甘油酯消化均有显著改善（p<0.01）。在监测门诊患者时，粪便14C-三油酸甘油酯-3H-油酸试验最为可靠。
