Lião Luciano M, Silva Gilmar A, Monteiro Marcos R, Albuquerque Sérgio
Instituto de Química, Universidade Federal de Goiás, Campus Samambaia, C. P. 131, 74001-970 Goiânia, GO, Brazil.
Z Naturforsch C J Biosci. 2008 Mar-Apr;63(3-4):207-10. doi: 10.1515/znc-2008-3-408.
We report the trypanocidal activity of quinonemethide triterpenoids isolated from root extracts of Cheiloclinium cognatum, a plant of the Hippocrateaceae family, collected in the Cerrado Reserve at Universidade Federal de Goiás, Brazil. The trypanocidal activity assays showed an effect on the blood trypomastigote forms of the Y strain of Trypanosoma cruzi where tingenone and tingenol demonstrated activity on the parasite. Their structures were elucidated on the basis of spectral data, particularly COSY, HMQC and HMBC experiments, and chemical transformations.
我们报道了从巴西戈亚斯联邦大学塞拉多保护区采集的希波克拉底科植物Cognatum Cheiloclinium根提取物中分离得到的醌甲基三萜类化合物的杀锥虫活性。杀锥虫活性测定显示，对克氏锥虫Y株的血液型锥鞭毛虫形式有影响，其中tingenone和tingenol对该寄生虫表现出活性。基于光谱数据，特别是COSY、HMQC和HMBC实验以及化学转化，阐明了它们的结构。
