Biavatti M W, Vieira P C, Fernandes J B, Albuquerque S, Magalhães C M, Pagnocca F C
Departamento de Química, Universidade Federal de São Carlos, SP, Brazil.
Phytomedicine. 2001 Mar;8(2):121-4. doi: 10.1078/0944-7113-00016.
The hexane extract of the stems of Raulinoa echinata afforded the sesquiterpenes germacrene D (6), 1beta,6alpha-dihydroxy-4-(15)-eudesmene (4) and oplopanone (5); the triterpenes squalene, isomultiflorenol (7), isobauerenol (8) and friedelin (9); the protolimonoids melianone (2) and melianodiol (3); and the pyranocoumarin 3-(1'-1'-dimethylallyl)-lomatin (1), which has not been reported previously as a natural product; together with beta-sitosterol. The hexane extract and some of these compounds were assayed in vitro against trypomastigote forms of Trypanosoma cruzi. Brine shrimp lethality and antimicrobial activities of the crude extract and pure compounds were also evaluated.
糙叶劳里木茎的己烷提取物得到了倍半萜类化合物吉马烯 D（6）、1β,6α - 二羟基 - 4 -（15）- 桉叶烯（4）和奥普洛潘酮（5）；三萜类化合物角鲨烯、异多花醇（7）、异鲍尔烯醇（8）和蛇麻脂醇（9）；原柠檬苦素类化合物美里酮（2）和美里二醇（3）；以及吡喃香豆素 3 -（1'-1'- 二甲基烯丙基）- 洛马亭（1），该化合物此前未作为天然产物被报道；还得到了β - 谷甾醇。对己烷提取物和其中一些化合物进行了体外抗克氏锥虫无鞭毛体形式的试验。还评估了粗提物和纯化合物的卤虫致死活性及抗菌活性。
