Roca-Mézquita Carolina, Graniel-Sabido Manlio, Moo-Puc Rosa E, Leon-Déniz Lorena V, Gamboa-León Rubí, Arjona-Ruiz Carely, Tun-Garrido Juan, Mirón-López Gumersindo, Mena-Rejón Gonzalo J
Facultad de Química, Universidad Autónoma de Yucatán, C. 41 No. 421 Col. Industrial, C.P. 97150, Mérida, Yucatán, México.
Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad, Centro Médico "Ignacio García Téllez", IMSS, C. 41, No. 439, Col. Industrial, C.P. 97150, Mérida, Yucatán, México.
Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):162-165. doi: 10.21010/ajtcam.v13i4.21. eCollection 2016.
Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of , a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases.
Dichloromethane and methanol extracts of leaves, bark and roots of were tested against , , , and . A quantitative HPLC analysis of pristimerin and tingenone was performed.
The dichloromethane extract of roots was active against , , , and , at IC50's of 0.80, 0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%).
The dichloromethane extract of the roots bark showed significant activity against all screened protozoa.
恰加斯病、阿米巴病、贾第虫病和滴虫病在拉丁美洲是严重的健康问题。用于治疗这些疾病的药物会产生重要的副作用，并且已经出现了耐药菌株。本研究旨在评估一种卫矛科植物（在墨西哥用于治疗发热型疾病的抗感染药物）的叶、茎皮和根皮的抗原虫活性。
测试了该植物叶、树皮和根的二氯甲烷和甲醇提取物对克氏锥虫、溶组织内阿米巴、蓝氏贾第鞭毛虫和阴道毛滴虫的活性。对扁蒴藤素和卫矛醇进行了定量高效液相色谱分析。
根的二氯甲烷提取物对克氏锥虫、溶组织内阿米巴、蓝氏贾第鞭毛虫和阴道毛滴虫有活性，IC50分别为0.80、0.44、0.46和2.68μg/mL。高效液相色谱分析显示存在卫矛醇（3.84%）和扁蒴藤素（0.14%）。
根皮的二氯甲烷提取物对所有筛选的原生动物显示出显著活性。
