[大孔吸附树脂法分离纯化两面针根中生物碱]
[Separation and purification of alkaloids from radix of Zanthoxylum nitidum by macroporous adsorption resin].
作者信息
Liu Shao, Zhang Wei, Lei Peng, Li Xin-Zhong, Liang Yi-Zeng
机构信息
Department of Pharmacy, Xiangya Hospital, Center South University, Changsha 410008, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2008 Feb;33(4):377-9.
OBJECTIVE
To obtain the optimal conditions for separating the alkaloids from the extract of Radix of Zanthoxylum nitidum by selecting appropriate macroporous adsorption resins.
METHOD
Eight types of macroporous adsorption were evaluated in separating efficiency with measuring the adsorption ratio and eluting ratio of Alkaloids as indexes.
RESULT
The XDA-5 macroporous adsorption resin had the best separating efficiency. After enrichment and purification with it, the product purity and yield of alkaloids were up to 33.25% and 90.15%, respectively.
CONCLUSION
This method is simple, feasible and fit for industry production.
目的
通过选择合适的大孔吸附树脂，获得从两面针根提取物中分离生物碱的最佳条件。
方法
以生物碱的吸附率和洗脱率为指标，评价8种大孔吸附树脂的分离效率。
结果
XDA - 5大孔吸附树脂分离效率最佳。用其进行富集纯化后，生物碱产品纯度和收率分别达到33.25%和90.15%。
结论
该方法简单、可行，适合工业化生产。
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