Masullo Milena, Bassarello Carla, Suzuki Hisanori, Pizza Cosimo, Piacente Sonia
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy.
J Agric Food Chem. 2008 Jul 9;56(13):5205-10. doi: 10.1021/jf800416j. Epub 2008 Jun 6.
In light of the wide range of biological activities of garcinol and with the aim of exploring some of them, we carried out its isolation from the fruits of Garcinia cambogia L. (Guttiferae). Surprisingly, the fruits were also found to contain guttiferones I, J, and K, compounds never reported in G. cambogia, along with three new compounds, namely, guttiferone M (1), guttiferone N (2), and the oxidized derivative of guttiferone K (6). Oxy-guttiferone K (6) is the first example of tetracyclic xanthone derived from the oxidation of a polyisoprenylated benzophenone from natural source. The natural formation of oxy-guttiferone K is in agreement with the previously described cyclization of garcinol by DPPH.
鉴于藤黄脂具有广泛的生物活性，并且为了探索其中的一些活性，我们从藤黄果（藤黄科）的果实中对其进行了分离。令人惊讶的是，在这些果实中还发现了藤黄酮I、J和K，这些化合物在藤黄果中从未有过报道，同时还发现了三种新化合物，即藤黄酮M（1）、藤黄酮N（2）以及藤黄酮K的氧化衍生物（6）。氧化藤黄酮K（6）是天然来源的聚异戊烯基化二苯甲酮氧化产生的四环呫吨酮的首个实例。氧化藤黄酮K的天然形成与之前所描述的藤黄脂通过二苯基苦味酰基自由基（DPPH）进行的环化反应一致。
