Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, New York 10468, United States.
J Nat Prod. 2010 Nov 29;73(11):1775-9. doi: 10.1021/np100322d. Epub 2010 Oct 28.
Two new polyisoprenylated benzophenones, 32-hydroxy-ent-guttiferone M (1) and 6-epi-guttiferone J (2), along with seven known compounds, 6-epi-clusianone (3), guttiferone A (4), xanthochymol (5), guttiferone E (6), isoxanthochymol (7), (+)-volkensiflavone (8), and (+)-morelloflavone (9), were identified from the seeds and rinds of Rheedia edulis. Compounds 1-3 and 5-9 have been isolated and identified from this species for the first time. The structures of the new compounds were elucidated mainly by analysis of their 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by comparison of their experimental optical rotation and electronic circular dichroism measurements with those values predicted by DFT calculations. Compound 1 showed significant antioxidant activity in both DPPH and ABTS free radical scavenging assays, whereas compound 2 was inactive.
两种新的多异戊二烯基二苯甲酮，32-羟基-ENT-金合欢素 M（1）和 6-epi-金合欢素 J（2），以及 7 种已知化合物，6-epi-clusianone（3）、金合欢素 A（4）、黄烷醇（5）、金合欢素 E（6）、异黄烷醇（7）、（+）-volkensiflavone（8）和（+）-morelloflavone（9），从 Rheedia edulis 的种子和果皮中被鉴定出来。化合物 1-3 和 5-9 是首次从该种植物中分离鉴定出来的。新化合物的结构主要通过对其 1D 和 2D NMR 波谱数据的分析来阐明，其绝对构型通过与实验旋光和电子圆二色性测量值与通过 DFT 计算预测的值进行比较来确定。化合物 1 在 DPPH 和 ABTS 自由基清除测定中均显示出显著的抗氧化活性，而化合物 2 则没有活性。
