Stranges Saverio, Dorn Joan M, Donahue Richard P, Browne Richard W, Freudenheim Jo L, Hovey Kathleen M, Trevisan Maurizio
Cardiovascular Medicine and Epidemiology Group, Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, UK.
Diabetes Care. 2008 Sep;31(9):1864-6. doi: 10.2337/dc08-0558. Epub 2008 Jun 5.
The purpose of this study was to analyze the interrelationship among oxidation, myocardial infarction (MI), and type 2 diabetes in a population-based case-control study of MI.
Participants were 1,709 individuals from western New York: 257 women and men with incident MI and 1,452 healthy control subjects (aged 35-70 years). Lipid peroxidation was measured by plasma levels of thiobarbituric acid reactive substances (TBARS). History of type 2 diabetes was determined by self-reported history of medical diagnosis.
In multivariate analyses, there was no significant difference in TBARS levels between case and control subjects in both sexes. In subgroup analyses by diabetes status, diabetic subjects, regardless of MI status, exhibited significantly higher TBARS values than nondiabetic subjects. For diabetic women, TBARS values were 1.84 and 1.83 nmol/ml for case and control subjects, respectively. Values for nondiabetic women were 1.29 and 1.31 nmol/ml, respectively. In diabetic men, values were 1.65 and 1.97 nmol/ml for case and control subjects, respectively. Values for nondiabetic men were 1.36 and 1.36 nmol/ml, respectively.
Whereas type 2 diabetes may be an important correlate of lipid peroxidation, clinical coronary heart disease may not.
本研究旨在通过一项基于人群的心肌梗死病例对照研究，分析氧化、心肌梗死（MI）和2型糖尿病之间的相互关系。
研究对象为来自纽约西部的1709名个体：257名发生心肌梗死的男性和女性，以及1452名健康对照者（年龄在35 - 70岁之间）。通过血浆硫代巴比妥酸反应性物质（TBARS）水平来测量脂质过氧化。2型糖尿病病史通过自我报告的医学诊断病史来确定。
在多变量分析中，男女病例组和对照组的TBARS水平均无显著差异。在按糖尿病状态进行的亚组分析中，无论是否患有心肌梗死，糖尿病患者的TBARS值均显著高于非糖尿病患者。对于糖尿病女性，病例组和对照组的TBARS值分别为1.84和1.83 nmol/ml。非糖尿病女性的值分别为1.29和1.31 nmol/ml。对于糖尿病男性，病例组和对照组的值分别为1.65和1.97 nmol/ml。非糖尿病男性的值分别为1.36和1.36 nmol/ml。
2型糖尿病可能是脂质过氧化的重要相关因素，而临床冠心病可能不是。
