Crockett Molly J, Clark Luke, Tabibnia Golnaz, Lieberman Matthew D, Robbins Trevor W
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
Science. 2008 Jun 27;320(5884):1739. doi: 10.1126/science.1155577. Epub 2008 Jun 5.
Serotonin (5-HT) has long been implicated in social behavior and impulsivity, but the mechanisms through which it modulates self-control remain unclear. We observed the effects of manipulating 5-HT function on behavior in the ultimatum game, where players must decide whether to accept or reject fair or unfair monetary offers from another player. Participants with depleted 5-HT levels rejected a greater proportion of unfair offers, but not fair offers, without showing changes in mood, fairness judgment, basic reward processing, or response inhibition. Our results suggest that 5-HT plays a critical role in regulating emotion during social decision-making.
血清素（5-羟色胺，5-HT）长期以来一直被认为与社会行为和冲动性有关，但其调节自我控制的机制仍不清楚。我们观察了操纵5-HT功能对最后通牒博弈行为的影响，在这个博弈中，玩家必须决定是否接受另一名玩家提出的公平或不公平的金钱提议。5-HT水平降低的参与者拒绝了更大比例的不公平提议，但不拒绝公平提议，且情绪、公平判断、基本奖励处理或反应抑制均未出现变化。我们的结果表明，5-HT在社会决策过程中的情绪调节中起关键作用。
