• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Targeted mutagenesis in zebrafish.

作者信息

Woods Ian G, Schier Alexander F

机构信息

Department of Molecular and Cellular Biology, Broad Institute, Center for Brain Science, Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

出版信息

Nat Biotechnol. 2008 Jun;26(6):650-1. doi: 10.1038/nbt0608-650.

DOI:10.1038/nbt0608-650
PMID:18536686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2602797/
Abstract
摘要

相似文献

1
Targeted mutagenesis in zebrafish.斑马鱼中的靶向诱变
Nat Biotechnol. 2008 Jun;26(6):650-1. doi: 10.1038/nbt0608-650.
2
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases.利用工程化锌指核酸酶在斑马鱼中进行靶向基因失活。
Nat Biotechnol. 2008 Jun;26(6):695-701. doi: 10.1038/nbt1398. Epub 2008 May 25.
3
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases.利用设计的锌指核酸酶在斑马鱼中进行可遗传的靶向基因破坏。
Nat Biotechnol. 2008 Jun;26(6):702-8. doi: 10.1038/nbt1409. Epub 2008 May 25.
4
Progress and prospects: techniques for site-directed mutagenesis in animal models.进展与展望:动物模型中定点诱变技术。
Gene Ther. 2009 May;16(5):581-8. doi: 10.1038/gt.2009.16. Epub 2009 Feb 19.
5
Targeted mutagenesis of zebrafish: use of zinc finger nucleases.斑马鱼的靶向诱变:锌指核酸酶的应用。
Birth Defects Res C Embryo Today. 2011 Sep;93(3):249-55. doi: 10.1002/bdrc.20213.
6
Engineered nucleases for targeted genome modification.
Curr Gene Ther. 2011 Feb;11(1):1. doi: 10.2174/156652311794520085.
7
A CRISPR approach to gene targeting.一种用于基因靶向的CRISPR方法。
Mol Ther. 2012 Sep;20(9):1658-1660. doi: 10.1038/mt.2012.171.
8
Construction and application of site-specific artificial nucleases for targeted gene editing.用于靶向基因编辑的位点特异性人工核酸酶的构建与应用
Methods Mol Biol. 2014;1101:267-303. doi: 10.1007/978-1-62703-721-1_13.
9
Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).利用寡聚体库工程(OPEN)技术制备的锌指核酸酶对内源斑马鱼基因进行快速突变。
PLoS One. 2009;4(2):e4348. doi: 10.1371/journal.pone.0004348. Epub 2009 Feb 9.
10
Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.工程化锌指核酸酶用于斑马鱼的靶向诱变
Methods Cell Biol. 2011;104:51-8. doi: 10.1016/B978-0-12-374814-0.00003-3.

引用本文的文献

1
An Overview of Zebrafish Modeling Methods in Drug Discovery and Development.斑马鱼在药物发现和开发中的建模方法概述。
Adv Exp Med Biol. 2022;1387:145-169. doi: 10.1007/5584_2021_684.
2
Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Homeostasis.临床和分子阐明弹力纤维松解症:内稳态范例。
Adv Exp Med Biol. 2021;1348:273-309. doi: 10.1007/978-3-030-80614-9_13.
3
High efficiency In Vivo genome engineering with a simplified 15-RVD GoldyTALEN design.高效的体内基因组工程,采用简化的 15-RVD GoldyTALEN 设计。
PLoS One. 2013 May 29;8(5):e65259. doi: 10.1371/journal.pone.0065259. Print 2013.
4
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting.通过Cas9/RNA介导的基因靶向技术生成基因编辑小鼠。
Cell Res. 2013 May;23(5):720-3. doi: 10.1038/cr.2013.46. Epub 2013 Apr 2.
5
Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat.锌指核酸酶介导的 LEW/Ztm 大鼠 Rag1 基因敲除。
BMC Immunol. 2012 Nov 8;13:60. doi: 10.1186/1471-2172-13-60.
6
Lessons from morpholino-based screening in zebrafish.基于 morpholino 的斑马鱼筛选的经验教训。
Brief Funct Genomics. 2011 Jul;10(4):181-8. doi: 10.1093/bfgp/elr021. Epub 2011 Jul 10.
7
Zebrafish as a model for normal and malignant hematopoiesis.斑马鱼作为正常和恶性造血模型。
Dis Model Mech. 2011 Jul;4(4):433-8. doi: 10.1242/dmm.006791.
8
Parkin is protective against proteotoxic stress in a transgenic zebrafish model.Parkin 可防止转基因斑马鱼模型发生蛋白毒性应激。
PLoS One. 2010 Jul 30;5(7):e11783. doi: 10.1371/journal.pone.0011783.
9
Progress and prospects: techniques for site-directed mutagenesis in animal models.进展与展望:动物模型中定点诱变技术。
Gene Ther. 2009 May;16(5):581-8. doi: 10.1038/gt.2009.16. Epub 2009 Feb 19.
10
Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).利用寡聚体库工程(OPEN)技术制备的锌指核酸酶对内源斑马鱼基因进行快速突变。
PLoS One. 2009;4(2):e4348. doi: 10.1371/journal.pone.0004348. Epub 2009 Feb 9.

本文引用的文献

1
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases.利用工程化锌指核酸酶在斑马鱼中进行靶向基因失活。
Nat Biotechnol. 2008 Jun;26(6):695-701. doi: 10.1038/nbt1398. Epub 2008 May 25.
2
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases.利用设计的锌指核酸酶在斑马鱼中进行可遗传的靶向基因破坏。
Nat Biotechnol. 2008 Jun;26(6):702-8. doi: 10.1038/nbt1409. Epub 2008 May 25.
3
Unexpected failure rates for modular assembly of engineered zinc fingers.工程化锌指蛋白模块化组装的意外失败率。
Nat Methods. 2008 May;5(5):374-5. doi: 10.1038/nmeth0508-374.
4
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.利用工程化锌指核酸酶在哺乳动物细胞中进行靶向基因敲除。
Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5809-14. doi: 10.1073/pnas.0800940105. Epub 2008 Mar 21.
5
Custom-designed zinc finger nucleases: what is next?定制设计的锌指核酸酶:接下来会怎样?
Cell Mol Life Sci. 2007 Nov;64(22):2933-44. doi: 10.1007/s00018-007-7206-8.
6
Design, construction and in vitro testing of zinc finger nucleases.锌指核酸酶的设计、构建及体外测试。
Nat Protoc. 2006;1(3):1329-41. doi: 10.1038/nprot.2006.231.
7
Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases.锌指工具:用于转录因子和核酸酶的定制DNA结合结构域。
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W516-23. doi: 10.1093/nar/gkl209.
8
Mutagenesis strategies in zebrafish for identifying genes involved in development and disease.用于鉴定参与发育和疾病的基因的斑马鱼诱变策略。
Trends Genet. 2006 Sep;22(9):473-8. doi: 10.1016/j.tig.2006.06.011. Epub 2006 Jul 17.
9
Highly efficient endogenous human gene correction using designed zinc-finger nucleases.利用设计的锌指核酸酶进行高效的内源性人类基因校正。
Nature. 2005 Jun 2;435(7042):646-51. doi: 10.1038/nature03556. Epub 2005 Apr 3.
10
Enhancing gene targeting with designed zinc finger nucleases.利用设计的锌指核酸酶增强基因靶向作用。
Science. 2003 May 2;300(5620):764. doi: 10.1126/science.1079512.