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天蓝色链霉菌中通过对absB操纵子转录本进行核糖核酸内切酶切割实现AbsB（核糖核酸酶III）表达的自动调节。

Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts.

作者信息

Xu Weijing, Huang Jianqiang, Cohen Stanley N

机构信息

Department of Genetics, MC5120, Stanford University School of Medicine, Stanford, California 94305, USA.

出版信息

J Bacteriol. 2008 Aug;190(15):5526-30. doi: 10.1128/JB.00558-08. Epub 2008 Jun 6.

DOI:10.1128/JB.00558-08
PMID:18539734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2493247/
Abstract

The Streptomyces coelicolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibiotic biosynthesis. Here we report that AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript. Our results demonstrate a ribonucleolytic regulatory role for AbsB in vivo.

摘要

天蓝色链霉菌的absB基因编码一种核糖核酸酶III家族的内切核糖核酸酶，通常对抗生素生物合成至关重要。在此，我们报道AbsB通过顺序且位点特异性地切割其多顺反子转录本的茎环片段来控制自身表达。我们的结果证明了AbsB在体内具有核糖核酸酶解调控作用。

相似文献

1
Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts.天蓝色链霉菌中通过对absB操纵子转录本进行核糖核酸内切酶切割实现AbsB（核糖核酸酶III）表达的自动调节。
J Bacteriol. 2008 Aug;190(15):5526-30. doi: 10.1128/JB.00558-08. Epub 2008 Jun 6.
2
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本文引用的文献

1
The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation.天蓝色链霉菌中编码核糖核酸酶III的基因在指数生长期转录，是抗生素生产和正常孢子形成所必需的。
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Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor.天蓝色链霉菌不同抗生素生物合成途径之间的交叉调控。
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The absB gene encodes a double strand-specific endoribonuclease that cleaves the read-through transcript of the rpsO-pnp operon in Streptomyces coelicolor.absB基因编码一种双链特异性核糖核酸内切酶，该酶可切割天蓝色链霉菌中rpsO-pnp操纵子的通读转录本。
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A Streptomyces coelicolor antibiotic regulatory gene, absB, encodes an RNase III homolog.天蓝色链霉菌抗生素调控基因absB编码一种核糖核酸酶III同源物。
J Bacteriol. 1999 Oct;181(19):6142-51. doi: 10.1128/JB.181.19.6142-6151.1999.
10
1995 Colworth Prize Lecture. The regulation of antibiotic production in Streptomyces coelicolor A3(2).1995年科尔沃思奖讲座。天蓝色链霉菌A3(2)中抗生素生产的调控
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