天蓝色链霉菌中通过对absB操纵子转录本进行核糖核酸内切酶切割实现AbsB（核糖核酸酶III）表达的自动调节。
Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts.
作者信息
Xu Weijing, Huang Jianqiang, Cohen Stanley N
机构信息
Department of Genetics, MC5120, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
J Bacteriol. 2008 Aug;190(15):5526-30. doi: 10.1128/JB.00558-08. Epub 2008 Jun 6.
Abstract
The Streptomyces coelicolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibiotic biosynthesis. Here we report that AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript. Our results demonstrate a ribonucleolytic regulatory role for AbsB in vivo.
摘要
天蓝色链霉菌的absB基因编码一种核糖核酸酶III家族的内切核糖核酸酶，通常对抗生素生物合成至关重要。在此，我们报道AbsB通过顺序且位点特异性地切割其多顺反子转录本的茎环片段来控制自身表达。我们的结果证明了AbsB在体内具有核糖核酸酶解调控作用。
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Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts.天蓝色链霉菌中通过对absB操纵子转录本进行核糖核酸内切酶切割实现AbsB（核糖核酸酶III）表达的自动调节。
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