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膀胱内卡介苗治疗浅表性膀胱癌并发肝脏肉芽肿性结核的管理

Management of hepatic granulomatous tuberculosis complicating intravesical BCG for superficial bladder cancer.

作者信息

Fradet Vincent, Gaudreau Christiane, Perrotte Paul, Côté Jean, Paquin Jean-Marie

机构信息

Departement of Surgery (urology), the Department of Microbiology and the Department of Pathology, Centre Hospitalier de l'Université de Montréal-Hôpital St-Luc, Montréal, Que.

出版信息

Can Urol Assoc J. 2007 Sep;1(3):269-72. doi: 10.5489/cuaj.83.

DOI:10.5489/cuaj.83
PMID:18542802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2422975/
Abstract

Intravesical bacille Calmette-Guérin (BCG) therapy is the most effective treatment for high-risk superficial bladder cancer. Severe systemic complications are rare, but may occur in approximately 1% of cases. We report a severe complication of intravesical BCG: a disseminated Mycobacterium bovis infection with biopsy-proven granulomatous hepatitis in a patient with bladder cancer. We also elaborate on the different management alternatives.

摘要

膀胱内卡介苗（BCG）治疗是高危浅表性膀胱癌最有效的治疗方法。严重的全身并发症很少见，但约1%的病例可能会发生。我们报告了一例膀胱内卡介苗治疗的严重并发症：一名膀胱癌患者发生播散性牛分枝杆菌感染，经活检证实为肉芽肿性肝炎。我们还详细阐述了不同的处理方法。

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Management of hepatic granulomatous tuberculosis complicating intravesical BCG for superficial bladder cancer.膀胱内卡介苗治疗浅表性膀胱癌并发肝脏肉芽肿性结核的管理
Can Urol Assoc J. 2007 Sep;1(3):269-72. doi: 10.5489/cuaj.83.
2
A Case of Epididymo-orchitis after intravesical bacille Calmette-Guérin therapy for superficial bladder carcinoma in a patient with latent tuberculosis infection.1例潜伏性结核感染患者在接受卡介苗膀胱内灌注治疗浅表性膀胱癌后发生附睾睾丸炎。
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Disseminated Mycobacterium bovis Infection Complicating Intravesical BCG Instillation for the Treatment of Superficial Transitional Cell Carcinoma of the Bladder.播散性牛分枝杆菌感染并发膀胱内卡介苗灌注治疗浅表性膀胱移行细胞癌
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Histopathology of Disseminated Mycobacterium bovis Infection Complicating Intravesical BCG Immunotherapy for Urothelial Carcinoma.膀胱内卡介苗免疫治疗尿路上皮癌并发播散性牛分枝杆菌感染的组织病理学
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Am J Gastroenterol. 1993 Jul;88(7):1112-5.
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[Granulomatous hepatitis revealing a Mycobacterium bovis widespread infection following intravesical BCG therapy].[卡介苗膀胱灌注治疗后播散性牛分枝杆菌感染所致的肉芽肿性肝炎]
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Systemic bacillus Calmette-Guerin infection in patients treated by intravesical BCG therapy for superficial bladder cancer.接受膀胱内卡介苗治疗浅表性膀胱癌的患者发生全身性卡介苗感染。
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Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature.卡介苗（BCG）膀胱内灌注作为膀胱癌辅助治疗后的感染：单中心系列研究中的发病率、危险因素及结局，并对文献进行综述
Medicine (Baltimore). 2014 Oct;93(17):236-254. doi: 10.1097/MD.0000000000000119.
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Concurrent granulomatous hepatitis, pneumonitis and sepsis as a complication of intravesical BCG immunotherapy.并发肉芽肿性肝炎、肺炎和败血症作为膀胱内卡介苗免疫疗法的一种并发症。
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本文引用的文献

1
Skin abscess after intravesical instillation of bacillus Calmette-Guerin for prophylactic treatment of transitional cell carcinoma.膀胱内灌注卡介苗预防移行细胞癌后发生皮肤脓肿。
J Urol. 2002 Sep;168(3):1094-5. doi: 10.1016/S0022-5347(05)64584-3.
2
[Can ofloxacin constitute an alternative antitubercular treatment for BCG hepatitis?].
Prog Urol. 2002 Apr;12(2):309-12.
3
Immunotherapy for bladder cancer.膀胱癌的免疫疗法。
Curr Urol Rep. 2001 Feb;2(1):62-9. doi: 10.1007/s11934-001-0027-7.
4
[Tolerance and efficiency of intravesical instillation of Calmette-Guérin in the prophylactic treatment of superficial bladder tumors, using a maintenance treatment].
Prog Urol. 2001 Sep;11(4):647-56.
5
[Evaluation of tolerance to endovesical BCG treatment in France: analysis of severe adverse effects notified in 3 years].[法国膀胱内卡介苗治疗耐受性评估：对3年内通报的严重不良反应的分析]
Prog Urol. 2001 Jun;11(3):458-65.
6
The fate of bacillus Calmette-Guerin after intravesical instillation.卡介苗膀胱内灌注后的转归
J Urol. 2001 May;165(5):1765-8.
7
Tolerability of bacille Calmette-Guérin maintenance therapy for superficial bladder cancer.
Urology. 2001 May;57(5):883-8. doi: 10.1016/s0090-4295(00)01117-1.
8
Utility of PCR assays for rapid diagnosis of BCG infection in children.聚合酶链反应检测在儿童卡介苗感染快速诊断中的应用
Int J Tuberc Lung Dis. 2001 Apr;5(4):380-4.
9
BCG immunotherapy: be cautious of granulomas. Disseminated BCG infection and mycotic aneurysm as late complications of intravesical BCG instillations.卡介苗免疫疗法：谨防肉芽肿。卡介苗播散性感染和霉菌性动脉瘤作为膀胱内卡介苗灌注的晚期并发症。
Neth J Med. 2001 Feb;58(2):71-5. doi: 10.1016/s0300-2977(00)00098-x.
10
Efficacy and safety of bacille Calmette-Guérin immunotherapy in superficial bladder cancer.卡介苗免疫疗法在浅表性膀胱癌中的疗效与安全性
Clin Infect Dis. 2000 Sep;31 Suppl 3:S86-90. doi: 10.1086/314064.