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卡介苗治疗膀胱癌后肝肉芽肿性结核的管理

Management of Hepatic Granulomatous Tuberculosis After BCG Therapy for Bladder Cancer.

作者信息

Ayati Mohsen, Nowroozi Mohammad Reza, Mortazavi Afshin, Ohadian Moghadam Solmaz, Ghorani Hossein

机构信息

Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Urol Case Rep. 2017 May 25;13:158-159. doi: 10.1016/j.eucr.2017.04.011. eCollection 2017 Jul.

DOI:10.1016/j.eucr.2017.04.011
PMID:28567336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5447372/
Abstract

BCG therapy is used as a treatment in bladder cancer. Intravesical administration of Bacillus Calmette-Guérin is used as a treatment method in superficial bladder cancer. While it is commonly effective, some serious side effects may occur. We hereby report a 65-year-old man who developed granulomatous hepatitis as a complication following BCG therapy. He was treated successfully with antitubercular therapy and prednisolone.

摘要

卡介苗疗法被用于膀胱癌的治疗。膀胱内灌注卡介苗被用作浅表性膀胱癌的一种治疗方法。虽然它通常有效，但可能会出现一些严重的副作用。我们在此报告一名65岁男性，他在卡介苗治疗后发生了肉芽肿性肝炎作为并发症。他通过抗结核治疗和泼尼松龙成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd1/5447372/00ef047dd661/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd1/5447372/baf9e98c8c56/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd1/5447372/00ef047dd661/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd1/5447372/baf9e98c8c56/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd1/5447372/00ef047dd661/gr2.jpg

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本文引用的文献

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Management of hepatic granulomatous tuberculosis complicating intravesical BCG for superficial bladder cancer.膀胱内卡介苗治疗浅表性膀胱癌并发肝脏肉芽肿性结核的管理
Can Urol Assoc J. 2007 Sep;1(3):269-72. doi: 10.5489/cuaj.83.
2
Bacillus Calmette-Guerin versus epirubicin for primary, secondary or concurrent carcinoma in situ of the bladder: results of a European Organization for the Research and Treatment of Cancer--Genito-Urinary Group Phase III Trial (30906).卡介苗与表柔比星治疗原发性、继发性或同时性膀胱原位癌：欧洲癌症研究与治疗组织-泌尿生殖组III期试验（30906）的结果
J Urol. 2005 Feb;173(2):405-9. doi: 10.1097/01.ju.0000150425.09317.67.
3
分枝杆菌与癌症的关系具有双重性。
Int J Mol Sci. 2021 Aug 3;22(15):8332. doi: 10.3390/ijms22158332.
4
Myeloid cell TNFR1 signaling dependent liver injury and inflammation upon BCG infection.BCG 感染时依赖于髓样细胞 TNFR1 信号的肝损伤和炎症。
Sci Rep. 2019 Mar 28;9(1):5297. doi: 10.1038/s41598-019-41629-9.
Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a meta-analysis of the published results of randomized clinical trials.
膀胱内灌注卡介苗可降低浅表性膀胱癌患者的疾病进展风险：一项对已发表的随机临床试验结果的荟萃分析。
J Urol. 2002 Nov;168(5):1964-70. doi: 10.1016/S0022-5347(05)64273-5.
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Immunotherapy for bladder cancer.膀胱癌的免疫疗法。
Curr Urol Rep. 2001 Feb;2(1):62-9. doi: 10.1007/s11934-001-0027-7.