乳腺癌中的癌症干细胞：当前观点与未来挑战
Cancer stem cells in breast: current opinion and future challenges.
作者信息
Charafe-Jauffret Emmanuelle, Monville Florence, Ginestier Christophe, Dontu Gabriela, Birnbaum Daniel, Wicha Max S
机构信息
Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
出版信息
Pathobiology. 2008;75(2):75-84. doi: 10.1159/000123845. Epub 2008 Jun 10.
Abstract
There is increasing evidence for the cancer stem cell hypothesis, which holds that cancers are driven by a cellular subcomponent that has stem cell properties, that is, self-renewal, tumorigenicity and multilineage differentiation capacity. The cancer stem cell hypothesis modifies our conceptual approach of oncogenesis and shall have implications in breast cancer prevention, detection and treatment, especially in metastatic breast cancer for which no curative treatment exists. Given the specific stem cell features, novel therapeutic pathways can be targeted. Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative.
摘要
癌症干细胞假说的证据越来越多，该假说认为癌症是由具有干细胞特性的细胞亚成分驱动的，即自我更新、致瘤性和多谱系分化能力。癌症干细胞假说改变了我们对肿瘤发生的概念性认识，并且将对乳腺癌的预防、检测和治疗产生影响，尤其是在尚无治愈性疗法的转移性乳腺癌方面。鉴于特定的干细胞特征，可以靶向新的治疗途径。按照这种方法，目前正在开发新的分子。关注干细胞与其微环境之间的相互作用也是探索如何更好地靶向癌症干细胞并实现治愈的一种有前景的方式。
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