Qi Tongtong, Dong Yonghong, Gao Zili, Xu Jun
Department of General Surgery, Shanxi Medical University, Taiyuan, Shanxi 030001, People's Republic of China.
Department of Gastroenteropancreatic & Hernia Surgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, People's Republic of China.
Onco Targets Ther. 2020 Dec 8;13:12587-12599. doi: 10.2147/OTT.S281328. eCollection 2020.
Huaier (), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and metastasis, arresting cell cycle, inducing apoptosis, pyrosis, and autophagy, anti-intratumoral angiogenesis, attenuating characteristics of tumor stem-like cells, interfering with the function of the tumor-related immune system, reversing drug resistance, and enhancing the sensitivity to chemotherapeutic drugs, etc. In addition, studies suggest that non-coding RNA (ncRNA) acts a pivotal part in cancer occurrence and development, and demonstrates that Huaier adjusts the performance of certain lncRNA (long non-coding RNA) and proceeds to affect the microRNA and its target genes, rendering an anti-tumor effect. Huaier also modulates the expression of lncRNA to attenuate the activity of ncRNA-sponged microRNA and then inhibits the expression of downstream target genes. We summarize and illustrate the experimentally confirmed anti-cancer molecular mechanisms of Huaier, to inspire new ideas for researchers in relevant fields.
槐耳，一种中国传统草药，在各种肿瘤的临床治疗中已显示出有前景的疗效。有文献记载的实验表明了槐耳的生物学功能及其抗肿瘤分子机制：抑制增殖和转移、阻滞细胞周期、诱导凋亡、坏死和自噬、抗肿瘤内血管生成、减弱肿瘤干细胞样细胞的特性、干扰肿瘤相关免疫系统的功能、逆转耐药性以及增强对化疗药物的敏感性等。此外，研究表明非编码RNA（ncRNA）在癌症发生和发展中起关键作用，并且证明槐耳可调节某些长链非编码RNA（lncRNA）的表现，并进而影响微小RNA及其靶基因，产生抗肿瘤作用。槐耳还可调节lncRNA的表达以减弱ncRNA海绵化微小RNA的活性，进而抑制下游靶基因的表达。我们总结并阐述了经实验证实的槐耳抗癌分子机制，为相关领域的研究人员提供新思路。
