Benito-Orejas J I, Ramírez B, Morais D, Almaraz A, Fernández-Calvo J L
ENT Department, Hospital Clínico Universitario, Valladolid, Spain.
Int J Pediatr Otorhinolaryngol. 2008 Aug;72(8):1193-201. doi: 10.1016/j.ijporl.2008.04.011. Epub 2008 Jun 12.
Both transitory auditory otoemissions (TEOAE) and automated auditory brainstem responses (AABR) are considered adequate methods for universal hearing screening. The goal of this study was to compare the results obtained with each device, applying the same screening procedure.
From 2001 to 2003, all the newborns in our health area (2454 infants) were evaluated with TEOAE (ILO92, otodynamics) and all those born from 2004 to 2006 (3117) were evaluated with AABR (AccuScreen, Fischer-Zoth). The population studied included all well newborns and those admitted to neonatal intensive care units (NICU). The first screening was normally undertaken with well babies during the first 48h of life, before hospital discharge. Infants referred from this first step underwent a second screening after hospital discharge, before they were a month old.
The results from each study group were compared and analyzed for significant differences. TEOAE screening yielded 10.2% fail results from the first screening step; AABR gave 2.6%. In the second screening step, 2% of the newborns screened with TEOAE were referred, whereas 0.32% of those screened with AABR were referred. These differences are statistically significant.
Although AABR screening tests involve a slightly higher cost in time and money than TEOAE, the results obtained compensate this difference. AABR gives fewer false positives and a lower referral rate; the percent of infants lost during follow-up is consequently smaller. Therefore, in our environment, universal newborn auditory screening with AABR is more effective than that with TEOAE.
瞬态耳声发射(TEOAE)和自动听性脑干反应(AABR)均被视为通用听力筛查的合适方法。本研究的目的是在应用相同筛查程序的情况下,比较使用每种设备获得的结果。
2001年至2003年,对我们健康区域内的所有新生儿(2454名婴儿)进行了TEOAE(ILO92,耳动力学)评估,对2004年至2006年出生的所有新生儿(3117名)进行了AABR(AccuScreen,Fischer-Zoth)评估。研究人群包括所有健康新生儿以及入住新生儿重症监护病房(NICU)的新生儿。首次筛查通常在出生后48小时内,在健康婴儿出院前进行。从第一步转诊的婴儿在出院后、满一个月前接受了第二次筛查。
对每个研究组的结果进行了比较和分析,以寻找显著差异。TEOAE筛查在第一步筛查中得出10.2%的不合格结果;AABR为2.6%。在第二步筛查中,接受TEOAE筛查的新生儿中有2%被转诊,而接受AABR筛查的新生儿中有0.32%被转诊。这些差异具有统计学意义。
虽然AABR筛查测试在时间和金钱方面的成本略高于TEOAE,但所获得的结果弥补了这一差异。AABR产生的假阳性较少,转诊率较低;因此,随访期间丢失的婴儿百分比更小。所以,在我们的环境中,使用AABR进行通用新生儿听力筛查比使用TEOAE更有效。