Raijmakers Maarten T M, Kuijper Philip H M, Bakkeren Dirk L, Vader Huib L
Laboratory of Clinical Chemistry, Máxima Medical Centre, Veldhoven, The Netherlands.
Ann Clin Biochem. 2008 Nov;45(Pt 6):593-7. doi: 10.1258/acb.2008.008062. Epub 2008 Sep 9.
The principle of the erythrocyte sedimentation rate (ESR) as assessed by TEST 1 is different from that of Westergren-based methods. This could result in different influences on the tests by paraproteins.
We investigated the effect of paraproteins on ESR readings by TEST 1 (y) and the StarrSed (x), a Westergren-based method, in 142 patients with paraproteinaemia. Agreement (Passing-Bablok) and bias (Bland-Altman) between methods was investigated and compared with that of a control population.
A poor agreement between the two methods was found in patients with a paraprotein (y = 0.67x + 3.3) in comparison with that of the control population (y = 0.96x + 0.2). Large differences between methods were present when ESR readings were >40 mm/hour, but clinical interpretation was similar in 90% of cases. Linear regression showed a concentration dependent influence of paraproteins on ESR readings by the StarrSed, especially for immunoglobulin class IgM.
ESR readings by TEST 1 result in similar clinical interpretation for most subjects, but readings are less influenced by the presence of a paraprotein than those of a Westergren-based method.
通过检测1评估的红细胞沉降率（ESR）原理与基于魏氏法的方法不同。这可能导致副蛋白对检测结果产生不同影响。
我们研究了142例副蛋白血症患者中副蛋白对检测1（y）和基于魏氏法的StarrSed（x）的ESR读数的影响。研究了两种方法之间的一致性（Passing-Bablok）和偏倚（Bland-Altman），并与对照人群进行比较。
与对照人群（y = 0.96x + 0.2）相比，副蛋白血症患者中两种方法之间的一致性较差（y = 0.67x + 3.3）。当ESR读数>40毫米/小时时，两种方法存在较大差异，但90%的病例临床解读相似。线性回归显示副蛋白对StarrSed法的ESR读数有浓度依赖性影响，尤其是免疫球蛋白IgM类。
检测1的ESR读数对大多数受试者的临床解读相似，但读数受副蛋白存在的影响小于基于魏氏法的方法。
