Watanabe A, Korenaga D, Maehara Y, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Cancer. 1991 Aug 15;68(4):815-20. doi: 10.1002/1097-0142(19910815)68:4<815::aid-cncr2820680425>3.0.co;2-k.
Data on 100 patients who had undergone resection for poorly differentiated adenocarcinoma of the stomach with serosal invasion were examined to assess the prognostic significance of the DNA distribution pattern in relation to the histologic tumor cell aggregation pattern. DNA distribution patterns were classified into low and high ploidies and tumor cell aggregation patterns were classified into free-cell, small nest, and large nest types. The rates of high ploidy in the free-cell, small nest, and large nest types were 23.1%, 48.0%, and 66.7%, respectively, with a significant increase according to the degree of aggregation. The high ploidy group and large nest type had a higher incidence of lymphogenous and hematogenous metastasis than the low ploidy group and free-cell type, respectively. DNA ploidy had no prognostic value for the free-cell type of tumor, but differences in prognosis and the incidence of metastasis between the DNA ploidies were evident in the nest-forming type. Aneuploid tumors consisting of a poorly differentiated adenocarcinoma were those with nest formation, from the standpoint of histologic structure and metastatic behavior. The DNA analysis of poorly differentiated adenocarcinomas was of prognostic value, especially in the nest-forming type.
对100例行胃低分化腺癌伴浆膜侵犯切除术患者的数据进行分析，以评估DNA分布模式与肿瘤组织学细胞聚集模式相关的预后意义。DNA分布模式分为低倍体和高倍体，肿瘤细胞聚集模式分为游离细胞型、小巢型和大巢型。游离细胞型、小巢型和大巢型的高倍体率分别为23.1%、48.0%和66.7%，随着聚集程度增加而显著升高。高倍体组和大巢型分别比低倍体组和游离细胞型有更高的淋巴道和血行转移发生率。DNA倍体对游离细胞型肿瘤无预后价值，但在巢状形成型肿瘤中，DNA倍体之间的预后及转移发生率存在明显差异。从组织结构和转移行为来看，由低分化腺癌构成的非整倍体肿瘤为巢状形成型。低分化腺癌的DNA分析具有预后价值，尤其在巢状形成型中。
