Korenaga D, Mori M, Okamura T, Sugimachi K, Enjoji M
Cancer. 1986 Dec 1;58(11):2542-5. doi: 10.1002/1097-0142(19861201)58:11<2542::aid-cncr2820581130>3.0.co;2-1.
Nuclear DNA content was microspectrophotometrically measured in 18 patients with a mucosal carcinoma of the stomach less than 5 mm in diameter. The findings were compared with data on 56 patients with a lesion greater than 5 mm. DNA distribution patterns were grouped into low and high ploidies. A mucosal carcinoma, classed as high ploidy, was confirmed in 27.8%, 22.2%, and 28.9% of the lesions with a diameter of less than 5 mm, 5 to 20 mm, and 20 to 40 mm, respectively. In the high-ploidy group with a lesion exceeding 5 mm, there was a preponderance of an elevated lesion, well- and moderately differentiated adenocarcinomas, and location in the lower third of the stomach. Such pathologic features showed the same tendency in the high-ploidy group with a lesion less than 5 mm. An aneuploid carcinoma may be present even in a lesion confined to the mucosa, and less than 5 mm in diameter.
采用显微分光光度法对18例直径小于5mm的胃黏膜癌患者的核DNA含量进行了测定。将这些结果与56例病变大于5mm的患者的数据进行了比较。DNA分布模式分为低倍体和高倍体。直径小于5mm、5至20mm以及20至40mm的病变中，分别有27.8%、22.2%和28.9%的黏膜癌被确认为高倍体。在病变超过5mm的高倍体组中，隆起性病变、高分化和中分化腺癌以及胃下三分之一部位的病变占多数。在病变小于5mm的高倍体组中，此类病理特征呈现出相同的趋势。即使是局限于黏膜且直径小于5mm的病变中，也可能存在非整倍体癌。
