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[上气道疾病治疗中的内科及外科治疗选择]

[Medical and surgical treatment options in the management of upper airway diseases].

作者信息

Simmen Daniel B

机构信息

ORL-Zentrum, Klinik Hirslanden Zürich.

出版信息

Ther Umsch. 2008 Mar;65(3):175-80. doi: 10.1024/0040-5930.65.3.175.

Abstract

Rhinitis and sinusitis usually coexist and are concurrent in most individuals; thus, the correct terminology is now rhinosinusitis. Rhinosinusitis (acute and chronic, with and without nasal polyps) is defined as an inflammation of the nose and the paranasal sinuses characterised by two or more symptoms, one of which should be either nasal blockage, obstruction, congestion or nasal discharge (anterior and posterior nasal drip). For the acute rhinosinusitis one can state that the initial antibiotic treatment does not affect the outcome of the disease, therefore a symptomatic treatment as first line is adequate. Antibiotics are indicated after a prolonged phase of the disease with increase of the symptoms mainly after a period up to 10 days. An early treatment with topical steroids is most efficient in ARS. Chronic rhinosinusitis (CRS) is a multifactorial disease. Factors contributing can be mucociliary impairment, bacterial infection, allergy, swelling of the mucosa for another reason or anatomical variations in the nasal cavity. The ostiomeatal complex, a functional unit of the paranasal sinuses plays a key role in the pathogenesis of rhinosinusitis. The first line treatment strategy is medical treatment using topical steroids, long-term macrolide therapy and in severe cases short courses of systemic steroids. The role of surgery is defined to treat the residual disease after medical treatment. Surgery is primarily aimed at improving ventilation of the sinuses and restoring paranasal clearance.

摘要

鼻炎和鼻窦炎通常同时存在,在大多数个体中并发;因此,现在正确的术语是鼻-鼻窦炎。鼻-鼻窦炎(急性和慢性,伴或不伴鼻息肉)被定义为鼻腔和鼻窦的炎症,其特征为两种或更多症状,其中之一应为鼻塞、阻塞、充血或鼻分泌物(前后鼻滴漏)。对于急性鼻-鼻窦炎,可以说初始抗生素治疗不影响疾病的转归,因此一线对症治疗就足够了。在疾病持续较长时间且症状加重后,主要是在长达10天的一段时间后,才需要使用抗生素。早期使用局部类固醇治疗在急性鼻-鼻窦炎中最为有效。慢性鼻-鼻窦炎(CRS)是一种多因素疾病。促成因素可能是黏液纤毛功能障碍、细菌感染、过敏、黏膜因其他原因肿胀或鼻腔解剖变异。鼻窦的功能单位窦口鼻道复合体在鼻-鼻窦炎的发病机制中起关键作用。一线治疗策略是使用局部类固醇、长期大环内酯类药物治疗,严重病例短期使用全身类固醇药物。手术的作用是治疗药物治疗后残留的疾病。手术主要旨在改善鼻窦通气并恢复鼻窦引流。

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